补体C_5在心肌梗死死后诊断的特异性研究  

Study on the specificity of complement C_5 for the postmortem diagnosis of myocardial infarction

作　　者：胡丙杰[1] 陈玉川[1] 祝家镇[1] 毕启明[1] 李杰 曾家乐 李军[3] 

机构地区：[1]中山医科大学法医病理学教研室,广东广州510089 [2]东莞市公安局法医室,广东511700 [3]中山市公安局坦洲分局刑警大队,广东528467

出　　处：《法医学杂志》2001年第1期7-9,共3页Journal of Forensic Medicine

基　　金：卫生部科研基金!( 96- 1- 127);广东省自然科学基金!( 980078);卫生部优秀青年科技人才专项基金!( 970012);广东医学科研

摘　　要：为了探讨补体 C5在心肌梗死死后诊断的特异性，应用免疫组织化学和图像分析技术 ,对正常心脏、心肌梗死及其它非梗死性的引起直接或间接心脏损害的情况如心肌炎、窒息、电击死、出血性休克、心挫伤、有机磷中毒等心肌细胞内 C5的变化进行研究。结果发现： C5仅在心肌梗死与心肌炎病例出现阳性反应，其阳性反应面积同正常对照组存在显著性差异，在窒息、电击死、出血性休克、心挫伤、有机磷中毒等病例未见明显阳性反应。因此 C5作为心肌梗死死后诊断指标仅受心肌炎的影响，对诊断心肌梗死具有较好的特异性。In order to explore the specificity of complement C5 in the postmortem diagnosis of myocardial infarction, changes of C5 staining in normal, infarcted and other non－ infarcted myocardia with direct or indirect myocardial injuries (myocarditis, mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion and organophosphate poisoning) were studied with immunohistochemistry and image analysis. The results showed that positive C5 staining could be observed in groups of myocardial infarction and myocarditis, but not in groups of mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion, and organophosphate poisoning. It is indicated that positive reaction of C5 could only be affected by myocarditis, which means that it was more specific for the diagnosis of myocardial infarction.

关 键 词：心肌梗死 补体C5 免疫组织化学 图像分析 特异性 法医学 

分 类 号：R542.220.4[医药卫生—心血管疾病] D919[医药卫生—内科学]