血清谷氨酰转肽酶、碱性磷酸酶、腺苷脱氨酶联合糖类抗原CA19-9在黄疸鉴别中的意义  

Value of Serum GGT,ALP,ADA and CA19-9 in the Diagnosis of Jaundice

作　　者：倪丽娜[1,2] 栾希英[1] 

机构地区：[1]滨州医学院免疫学教研室 [2]威海市文登中心医院输血科

出　　处：《临床合理用药杂志》2014年第15期19-20,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨血清谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、腺苷脱氨酶(ADA)、糖类抗原CA19-9升高程度在黄疸类型鉴别中的价值。方法选取本院2011年1月—2013年10月收治的黄疸患者614例,根据黄疸类型将614位患者分为肝细胞性黄疸组和梗阻性黄疸组,后者又分为良性梗阻性黄疸和恶性梗阻性黄疸两组,分析GGT、ALP、ADA、CA19-9水平在各组间分布差异。结果 GGT、ALP值在梗阻性黄疸组中较肝细胞性黄疸组高,差异有统计学意义(P<0.05);ADA值在肝细胞性黄疸组较对照组与梗阻性黄疸组增高,差异有统计学意义(P<0.05);GGT、ALP、CA19-9值在恶性梗阻性黄疸组中较良性梗阻性黄疸组高,差异有统计学意义(P<0.05)。结论 GGT、ALP显著升高,而ADA无明显升高的黄疸考虑梗阻性黄疸;GGT、ALP轻中度升高,而ADA显著升高的黄疸考虑肝细胞性性黄疸;GGT、ALP、CA19-9均显著升高者考虑恶性梗阻性黄疸。Objective To investigate the value of serum GGT,ALP,ADA and CA19 - 9 in the diagnosis of jaun-dice. Methods 614 cases with jaundice were admitted to our hospital from January 2011 to October 2013,were divided into hepatocellular and obstructive jaundice group according to the type,and the patients in obstructive jaundice group were divided into benign obstructive jaundice group and malignant obstructive jaundice group. The distribution of serum GGT,ALP,ADA and CA19 - 9 in each group were analyzed. Results Compared with hepatocellular jaundice group,the serum level of GGT and ALP were higher in obstructive jaundice group,the differences were statistically significant（P 〈 0. 05）;Compared with obstruc-tive jaundice group,the serum level of ADA was higher in hepatocellular Jaundice group,the difference was statistically signifi-cant（P 〈 0. 05）;Compared with benign obstructive jaundice group,the serum levels of GGT,ALP and CA19 - 9 were higher in malignant obstructive jaundice group,the differences were statistically significant（P 〈 0. 05）. Conclusion Jaundice with marked elevation of serum GGT and ALP while no significant elevation of serum ADA is considered as obstructive jaundice;Jaundice with marked elevation of serum ADA while mild elevation of serum GGT and ALP are considered as hepatocellular jaun-dice;Jaundice with marked elevation of serum GGT,ALP and CA19 - 9 are considered as malignant obstructive jaundice.

关 键 词：谷氨酰转肽酶 碱性磷酸酶 腺苷脱氨酶 糖类抗原CA19—9 黄疸 

分 类 号：R442.4[医药卫生—诊断学]