单纯性肥胖儿童血清瘦素水平及内分泌指标变化  

Changes of Serum Leptin and Other Related Hormones Levels in Simple Obese Children

作　　者：肖锦华[1] 王亚萍[2] 徐燕[3] 高玉芬[3] 

机构地区：[1]无锡市第三人民医院放免中心,214041 [2]无锡市第三人民医院检验科,214041 [3]无锡市第三人民医院儿内科,214041

出　　处：《放射免疫学杂志》2001年第1期5-7,共3页Journal of Radioimmanology

摘　　要：目的 :探讨单纯性肥胖儿童血清瘦素 (Leptin)水平及其与内分泌激素之间的关系。方法 :用放免法检测了 38例肥胖儿童和 30例健康儿童的血清leptin、胰岛素 (Ins)、甲状腺素 (T3 、T4 )、及生长激素 (GH)水平。结果 :肥胖儿童血清leptin、Ins、T3 水平均显著高于健康对照组 (P均 <0 .0 1) ,T4 水平变化不明显 (P >0 .0 5 ) ,GH水平则显著低于健康对照组 (P <0 .0 1)。相关分析显示 ,肥胖儿童血清leptin与Ins水平呈正相关 (r=0 .46 ,P <0 .0 1)。结论 :单纯性肥胖儿童存在瘦素抵抗及内分泌代谢紊乱 ,后者与血清瘦素水平升高有关 ;Objective To measure the serum leptin concentration in simple obese children together with other four kinds of related hormones. Methods Serum Leptin、 Ins、 T 3、 T 4、 and GH levels were measured by radioimmunoassay in thirty-eight obese children and thirty healthy controls. Results The levels of serum leptin、 Ins and T 3 in obese group were dramatically higher than those in control group (all P<0.01). There was no significant difference in serum T 4 concentration between simple obese children and control group (P>0.05), Serum GH levels was significantly decreased in simple obese children (P<0.01). There was a positive correlation between serum leptin levels and lns levels (r=0.46, P<0.01). Conclusion In simple obese children there were leptin resistance and endocrine metabolic disturbances, the later might be correlated with the increase of serum leptin levels; It is suggested that Leptin resistance might play a key role in the development of obesity.

关 键 词：瘦素 胰岛素 生长激素 甲状腺素 肥胖 儿童 

分 类 号：R725.892[医药卫生—儿科]