利用纳米力学方法对皮肤进行超声组织定征的研究  

Ultrasonic tissue characterization of skin tissue using doublet mechanics method

作　　者：欧阳灵[1] 刘晓宙[1] 刘杰惠[1] 龚秀芬[1] 

机构地区：[1]南京大学声学研究所,近代声学教育部重点实验室,南京210093

出　　处：《物理学报》2014年第10期264-272,共9页Acta Physica Sinica

基　　金：国家重点基础研究发展计划(批准号:2012CB921504;2011CB707902);国家自然科学基金(批准号:11274166);声场声信息国家重点实验室基金(批准号:SKLA201207);中央高等学校基本科研基金(批准号:1113020403;1101020402)资助的课题~~

摘　　要：纳米力学方法适用于具有离散特性的材料.利用纳米力学方法,得出声波在多层皮肤组织中的波动方程.分别改变黑素瘤皮肤的泊松比、黑素瘤侵袭厚度(Breslow深度)、节间距离,计算多层皮肤结构模型对垂直入射纵声波的反射系数.同时计算了声速和声衰减系数随组织参数的变化.计算结果表明,可综合利用一定频率段内反射系数最小点数、声速和衰减系数的变化来表征正常皮肤和病变皮肤.Doublet mechanics （DM） is applied to materials with dispersing property. The wave equation in multi-layered skin tissue is obtained through the method of DM in this article. By changing the Poisson ratio in melanoma skin tissue, the growth and spread of melanoma （Breslow thickness）, the internode distance, the reflection coefficients of the longitudinal waves incident vertically in the multi-layered skin model are calculated. And the acoustic velocity and acoustic attenuation coefficient changing with tissue parameters are also calculated. The results show that we can synthesize the change of the number of the minimal reflection coefficient, acoustic velocity and attenuation coefficient to discriminate cancerous skin from normal skin within a certain frequency.

关 键 词：纳米力学 皮肤组织 超声组织定征 

分 类 号：O426[理学—声学]