别嘌醇对高尿酸血症扩张型心肌病患者心功能影响  

The cardiac function effect of allopurinol for hyperuricemia combined with dilated cardiomyopathy patients

作　　者：冷良[1] 马燕玲[1] 马玉英[1] 郑红俊[1] 冯义柏[1] 

机构地区：[1]华中科技大学附属协和医院西区内科,武汉430000

出　　处：《中国医师进修杂志》2014年第14期48-51,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨别嘌醇对高尿酸血症扩张型心肌病患者心功能的影响.方法 将120例高尿酸血症扩张型心肌病患者根据治疗方法不同分为别嘌醇组和对照组,每组60例.两组患者入院后均给予常规治疗,在此基础上对照组加用硝普钠治疗,而别嘌醇组加用别嘌醇和硝普钠治疗,两组均治疗3个月.结果 别嘌醇组总有效率明显高于对照组[90.0％ （54/60）比75.0％（45/60）],差异有统计学意义（P＜0.05）.别嘌醇组治疗后左室射血分数和左室收缩末期后壁厚度明显高于对照组[（67.85±7.12）％比（30.78±7.00）％和（1.40±0.20） mm比（1.16±0.18） mm],而左室收缩末期内径、左室舒张末期内径和左室舒张末期后壁厚度明显低于对照组[（4.72±0.41） mm比（6.48±0.47） mm、（2.93±0.32） mm比（5.56±0.62） mm和（0.77±0.13） mm比（0.92±0.18） mm],差异均有统计学意义（P＜0.05）.别嘌醇组治疗后尿酸、尿素氮和肌酐均明显低于对照组[（45.43±11.24）μmol/L比（167.23±19.22） μmol/L、（10.23±7.12） mmol/L比（40.93±8.09） mmol/L和（32.01±8.34） mmol/L比（78.09±9.11） mmol/L],差异均有统计学意义（P＜0.05）.结论 别嘌醇在降低高尿酸血症扩张型心肌病患者尿酸的同时,可早期逆转动脉硬化,改善心功能,值得推广应用研究.Objective To study the cardiac function effect of allopurinol for hypemricemia combined with dilated cardiomyopathy patients.Methods One hundred and twenty hypemricemia combined with dilated cardiomyopathy patients were divided into allopurinol group and control group according to the treatment method with 60 cases each.All the patients were given conventional treatment,the control group was added the nitroprusside treatment,and the allopurinol group was added the allopurinol and nitroprusside treatment.The treatment period was 3 months.Results The total effective rate in allopurinol group was significantly higher than that in control group [90.0% （54/60） vs.75.0% （45/60）],there was statistical difference （P 〈 0.05）.After treatment,the left ventricular ejection fraction and left ventricular posterior wall thickness at end-systole in allopurinol group were significantly higher than those in control group [（67.85 ± 7.12）% vs.（30.78 ±7.00）% and （1.40 ±0.20） mm vs.（1.16 ±0.18） mm[,but the left ventricular internal diameter at end-systole,left ventricular internal diameter at end-diastole and left ventricular posterior wall thickness at end-diastole were significantly lower than those in control group [（4.72 ± 0.41） mm vs.（6.48 ± 0.47） mm,（2.93 ± 0.32） mm vs.（5.56 ± 0.62） mm and （0.77 ± 0.13） mm vs.（0.92 ± 0.18） mm],there were statistical differences （P 〈 0.05）.After treatment,The uric acid,urea nitrogen and creatinine were significantly lower than those in control group [（45.43 ± 11.24） μ mol/L vs.（167.23 ± 19.22） μ mol/L,（10.23 ± 7.12）mmol/L vs.（40.93 ± 8.09）mmol/L and （32.01 ± 8.34） mmol/L vs.（78.09 ±9.11） mmol/L],there were statistical differences （P 〈 0.05）.Conclusion Allopurinol used for treating hyperuricemia combined with dilated cardiomyopathy patients can reduce uric acid,early reversal the atherosclerosis and improve heart function,it should be widely applied research.

关 键 词：别嘌呤醇 高尿酸血症 心肌病 扩张型 

分 类 号：R542.2[医药卫生—心血管疾病]