320排CT全肝灌注成像评价肝硬化微循环改变的临床价值  

Assessment of hepatic microvascular changes in liver cirrhosis by 320 row CT perfusion imaging

作　　者：林元为[1] 黄求理[1] 姜建帅[1] 陈伟建[2] 潘宇宁[1] 叶贤旺[1] 张杰[1] 

机构地区：[1]宁波市第一医院,宁波315000 [2]温州医学院附属第一医院

出　　处：《现代实用医学》2014年第5期518-519,522,共3页Modern Practical Medicine

基　　金：浙江省医药卫生平台重点资助项目(2012ZDA040)

摘　　要：目的探讨320排CT全肝灌注成像评价肝硬化血流动力学改变的可行性及价值。方法应用320排CT分别对29例肝硬化患者和17例非肝硬化患者行全脏灌注成像扫描,经后处理产生灌注参数图像,包括门静脉灌注量(PVP),肝动脉灌注量(HAP)及肝灌注指数(HPI),最后计算总肝灌注量(THBP)。结果肝硬化组THBP与PVP较正常对照组呈现下降的趋势,两组差异均有统计学意义(均P<0.05);而肝硬化组HPI和HAP较正常对照组呈现升高的趋势,两组差异均有统计学意义(均P<0.05)。结论 320排CT全肝灌注成像具有评价肝硬化患者全肝血流动力学变化的能力,可以作为一种新手段应用于临床相关研究。Objective To evaluate the value of 320 row CT perfusion imaging in assessing the hemodynamic changes of cirrhosis. Methods All of the patients in cirrhosis group and control group were selected to perform hepatic perfusion by a 320 row CT scanner. The parameters of hepatic perfusion were calculated, including portal vein perfusion（PVP）, hepatic artery perfusion（HAP） and hepatic perfusion index（HPI）; and then, total hepatic perfusion（THBP） was calculated. Results Compare to the control group, THBP and PVP of the cirrhosis group showed a trend of decline（P ＆lt; 0.05）, and HAP and HPI of the cirrhosis group showed a trend of rise（P ＆lt; 0.05）. There were significant differences in all parameters between the two groups（P ＆lt; 0.05）. Conclusions It is an effective method to apply 320 row CT perfusion for assessing hepatic microvascular changes in liver cirrhosis, and which can serve as a new method for clinical research.

关 键 词：肝脏 体层摄影术 X线计算机 灌注成像 血流动力学 

分 类 号：R816.5[医药卫生—放射医学]