接活跌打膏抗炎镇痛作用考察  

Anti-inflammatory and the Analgesic Effects of Jiehuo Dieda Ointment

作　　者：覃博[1] 韦葛堇[1] 

机构地区：[1]解放军第303医院急诊科,南宁530021

出　　处：《中国药师》2014年第5期745-747,共3页China Pharmacist

摘　　要：目的:考察接活跌打膏的抗炎及镇痛作用。方法:采用角叉菜胶致大鼠足趾肿胀法、棉球致大鼠肉芽肿法观察接活跌打膏的抗炎作用;小鼠热板法和小鼠醋酸扭体法观察接活跌打膏的镇痛作用。结果:和模型组比较,在给药后2 h,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组可显著抑制角叉菜胶致大鼠足趾肿胀(P<0.05);和正常对照组比较,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组能抑制大鼠棉球肉芽组织干重(P<0.05);和正常对照组比较,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组能显著减少醋酸引起的小鼠扭体反应次数,在给药后60 min,能延长小鼠热板痛阈值(P<0.05或P<0.01)。结论:接活跌打膏具有显著的抗炎和镇痛作用。To study the anti-inflammatory and analgesic effects Of Jiehuo Dieda ointment. Methods： The anti-inflam- matory activity was observed by rat foot swelling model induced by carrageenan and rat cotton ball granuloma model, and writhing re-sponse in mice induced by acetic acid and hot-plate test were used to explore the analgesic effects. Results： Compared with that of model group, Jiehuo Dieda ointment 28 g·kg^-1,14 g·kg^-1 could significantly decrease rats hind paw swelling rate after 2 hours of ad- ministration. Compared with that of normal control group, Jiehuo Dieda ointment 28 g·kg^-1,14 g·kg^-1 could significantly decrease the weights of rats cotton ball granuloma, could significantly decrease the writhing times ,and increase the pain thresholdr after 60 rain of administration（ P 〈 0.05 ,P 〈 0.01 ）.Conclusion： Jiehuo Dieda Ointment had obviously anti-inflammatory and analgesia effects.

关 键 词：接活跌打膏 抗炎作用 镇痛作用 

分 类 号：R971.1[医药卫生—药品]