吉林松原地区CD36基因单体型与2型糖尿病的相关性研究  

Correlation between CD36 haplotype gene and type 2 diabetes in Jilin Songyuan region

作　　者：姚庆春[1] 杨秀丽[1] 郑寿焕[2] 李金姬 

机构地区：[1]吉林油田总医院内分泌科,138000 [2]吉林省延边大学附属医院内分泌科 [3]辽宁丹东第一医院

出　　处：《中国实用医药》2014年第11期7-9,共3页China Practical Medicine

摘　　要：目的对吉林松原郭尔罗斯自治县蒙古族和汉族人群中2型糖尿病(T2MD)患者CD36内含子3(intron 3)[TG]重复序列基因多态性分布情况进行研究,探讨该基因多态性与2型糖尿病的相关性。方法应用PCR和直接测序法对40例正常组和193例2型糖尿病患者CD36内含子3[TG]重复序列基因多态性进行分析。结果①CD36内含子3[TG]重复序列有5种单体型,即[TG]重复次数为11、12、13、15、16次。②正常组与2型糖尿病患者之间CD36内含子3[TG]重复序列各种单体型及基因型分布差异无统计学意义(P>0.05)。③蒙古族与汉族之间CD36内含子3[TG]重复序列各种单体型及基因型分布差异无统计学意义(P>0.05)。④CD36内含子3[TG]重复序列13次的单体型及基因型在蒙古族人群中正常组与2型糖尿病患者之间分布差异具有统计学意义(P<0.05)。结论 CD36内含子3[TG]重复次数13次的单体型是松原蒙古族发生2型糖尿病的危险基因。Objective To investigate the distribution of CD36 intron 3 [ TG ] repeat polymorphism in type 2 diabetes mellitus （T2DM） patients and to expore the correlation between the genetic polymorphism and type 2 diabetes mellitus （T2DM）. Methods Genotypes of CD36 were typed in 193 T2DM patients and 40 normal person by polymerase chain reaction（PCR） and PCR-direct sequencing. Results （1） Research Results found CD36 intron 3 （TG） there were five kinds of haplotype repeat sequences, namely [ TG ] repetitions for 11, 12, 13, 15, 16. （2） The distribution of CD36 intron 3 [ TG ] repeat genotype or haplotype has no significant difference between normal control group and T2DM group （P〉0.05）. （3） The distribution of CD36 intron 3 [ TG ] repeat genotype or haplotype has no significant difference between the Moggol nationality and the Han nationality （P〉0.05）. （4） The distribution of CD36 intron 3 [ TG ] repeat for 13 times exist statistically significant difference in the Moggol nationality between normal control group and T2DM group （P〈0.05）. Conclusion The distribution of CD36 intron 3 [ TG ] repeat for 13 times haplotype is a risk genes of type 2 diabetes in the Moggol nationality of songyuan region.

关 键 词：2型糖尿病 CD36 基因单体型 

分 类 号：R587.1[医药卫生—内分泌]