外阴阴道假丝酵母菌病致病菌种分布及药敏分析  

Investigation on pathogenic distribution and drug susceptibility of vulvovaginal candidiasis

作　　者：邱丽红[1] 郑玉兰[1] 

机构地区：[1]福建医科大学附属第一医院闽南分院,362800

出　　处：《中国实用医药》2014年第11期41-42,共2页China Practical Medicine

基　　金：福建医科大学附属第一医院闽南分院医学科研专项基金(项目编号:MNZX-10-5)

摘　　要：目的探讨外阴阴道假丝酵母菌病的致病菌种及其在体外对常用抗真菌药物的敏感性。方法采用科玛嘉真菌培养鉴定和ATBFUNCUS药敏试剂盒对310例外阴阴道假丝酵母菌病患者临床标本进行菌种分析和药敏试验。结果 310例外阴阴道假丝酵母菌病的致病菌主要为白假丝酵母菌265例,占85.48%,非白假丝酵母菌45例,其中热带假丝酵母菌32例,占10.32%,光滑假丝酵母菌9例,占2.9%,克柔假丝酵母菌4例,占11.30%。4种抗真菌药物的敏感性为两性霉素B(100%)、5-氟胞嘧啶(99.03%)、氟康唑(86.45%)、伊曲康唑(79.68%)。结论外阴阴道假丝酵母菌病的主要致病菌为白假丝酵母菌。不同菌种对常用抗真菌药物的敏感性存在差异,应根据药敏结果选择合理的抗真菌药物。Objective To study the pathogen and drug sesceptibility of vulvovaginal candidiasis in vitro.Methods Vaginal secretion sample were collected from 310 vulvovaginal candidiasis patients, pathogen identification and drug sensitivity tests were carried out with CHROMagar chromogenic culture media and ATBFUNCUS susceptibility kit. Results Among the 310 cases of VVC, Candida albicans was the main fungi, there were 265 strains of Candida albicans（85.48%）, 45 candida non-albicans.And among non-albicans, 32 candida tropicalis （10.32%）, 9 candida glabrata （2.9%）, 4 candida kruseii （1.30%）. The susceptibility of 4 common antifungal drugs were showed as following： amphotericin B 100%, flurocytosine 99.03%, fluconazol 86.45%, itraconazole 79.68%. Conclusion Candida albicans is the most common pathogenic candida species causing vulvovaginal candidiasis. Susceptibility to common antifungal drugs shows difference among variant species.We should choose reasonable antifungal drugs according to the Antifungal susceptibility testing result.

关 键 词：外阴阴道假丝酵母菌病 致病菌种 药敏试验 

分 类 号：R711.3[医药卫生—妇产科学] R446.5[医药卫生—临床医学]