2007-2013年东莞市不明原因夜间睡眠猝死综合征的流行病学特征分析  

An epidemiological survey on sudden unexplained nocturnal death syndrome in Dongguan city during 2007-2013

作　　者：余彬彬[1,2] 翟李俊 徐伦武[4] 郑金祥[1] 黄二文[1,5] 唐双柏[1] 刘超[5] 成建定[1] 

机构地区：[1]中山大学中山医学院法医学系,广东广州510080 [2]广东省公安厅机场公安局交管支队,广东广州510470 [3]佛山市南海区公安局刑警大队,广东佛山528200 [4]福建省南平市公安局延平分局,福建南平353000 [5]广州市公安局刑事科学技术研究所,广东广州510030

出　　处：《热带医学杂志》2014年第4期415-418,433,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金面上项目(81172901;81373238);中央高校基本科研业务费专项资金项目(11ykpy04);教育部留学回国人员科研启动基金(第44批2012-940);十二五科技支撑计划项目(2012BAK02B02);广东省自然科学基金(S2012010009045)

摘　　要：目的研究近年来东莞市不明原因夜间睡眠猝死综合征（SUNDS）的流行病学特征，探寻有关的病因学线索。方法收集东莞市2007－2013年SUNDS死亡病例，并在资料库中按年龄、性别和死亡时间相接近、1：1匹配死因明确者作为对照组，同时对两组病例按年龄、性别、籍贯、死亡月份、死亡时刻及职业划分亚组，对病例资料数据进行统计分析，研究该病的流行病学特征。结果2007－2013年东莞市SUNDS死亡病例共计565例；男女性别比为14．7：1；2007－2013年各年发病率分别为0．68／10万、0．79／10万、0．60／10万、1．24／10万、1．20／10万、1．65／10万、0．93／10万：年龄分布在17～55岁，中位年龄为35岁，与全死因组年龄分布差异有统计学意义；发病例数最高峰出现在3－6月份，最低在10－12月份，与当地全年月平均气温变化趋势存在相关性；死亡高峰时段为凌晨0－1点，例数较最低时段（凌晨3－4点）高出20多倍；病例籍贯来源最多为湖南省（93例），有发病“聚集性”的是云南省（病例组／对照组4．25倍）、香港（3．67倍）及海南（2倍）；SUNDS病例主要发生于劳动强度大、文化程度低的工厂一线工人、保安、清洁员等人群中。结论近年来东莞市SUNDS的年均发病率未见下降，提示发病的高危因素依然存在，须作进一步流行病学调查查明高危因素。Objective To study the epidemiological characteristics of Sudden Unexplained Nocturnal Death Syndrome （SUNDS）, and find out some relevant clues for etiological research. Methods We collected SUNDS cases found in Dongguan city during 2007-2013, then chose control group cases with age, gender and death period close/same to the SUNDS cases from the database. Meanwhile, we divided the case/control group cases into subgroup according to age, gender, birthplace, death month, death hour or occupation. The collected data were analyzed by statistical methods. Results There were 565 SUNDS cases in Dongguan city during 2007-2013, with a sex ratio of 14.7：l（male to female）. The annual incidence rate is 0.68/105,0.79/105,0.60/105, 1.24/105, 1.20/105, 1.65/105 and 0.93/105 respectively from 2007 to 2013. Age distribution range was from 17 to 55, with median age of 35. March to June was the outbreak peak period and October to November had the lowest incidence.This was in line with the change trend of local air temperature. Death of SUNDS mostly occurred during 0-1 AM, with the number of cases 20 times of that of the lowest. Most of the SUNDS cases came from Hunan province. Cluster SUNDS cases occurred in Yunnan, Hong Kong and Hainau province awere more than that of control group.SUNDS could be found mostly in low-education high-intensity labor workers.Conclusions In recent years, the incidence of SUNDS in Dongguan city remains the same. It revealed that risk factors of SUNS still existed, and more meticulous epidemiological research and intervention is needed to find out the underlying risk factors.

关 键 词：不明原因夜间睡眠猝死综合征 发病率 流行病学特征 

分 类 号：R541[医药卫生—心血管疾病]