PCT、hs-CRP表达量与冠状动脉粥样硬化病变程度的相关性研究  

Relationship of combined detection of hs-CRP and PCT and degree of coronary atherosclerosis

作　　者：刘志祥[1] 谢飞[1] 吴玉竹[1] 李文兵[1] 

机构地区：[1]湖北医药学院附属太和医院检验科,湖北十堰442000

出　　处：《热带医学杂志》2014年第4期498-500,共3页Journal of Tropical Medicine

摘　　要：目的探讨冠心病患者血清降钙素原（PCT）、超敏C反应蛋白（hs-CRP）表达量与冠状动脉粥样硬化病变程度的相关性。方法 118例冠状动脉造影术患者按造影结果分为冠心病组（n=89）和正常对照组（n=29），随即，采用改良Censini评分方法将冠心病组患者分为〈30分组（n=24）、30～60分组（n=37）和〉60分组（n=28），分别检测各组患者PCT和hs-CRP的含量。结果冠心病患者PCT和hs-CRP含量均显著高于对照组，差异有统计学意义（P〈0．05）；同时，冠心病患者PCT和hs-CRP含量随Gensini评分增加而逐渐上升，相关系数分别为0．88和0．90，呈正相关性（P〈0．05）。结论PCT、hs-CRP的含量与冠状动脉粥样硬化病变程度呈正相关．联合检测PCT和hs-CRP的含量有助于早期诊断冠状动脉粥样硬化引起的冠心病。Objective To discuss the relationship between the degree of coronary atherosclerosis and the level of hypersensitive C-reactive protein （hs-CRP） and procalcitonin （PCT）. Methods 118 patients with coronary artery angiography were selected for study, including coronary heart disease group （n=89） and normal control group （n=29）. According to the Gensini score system, coronary heart disease（CHD） patients were divided into three groups as 〈30 group （n=24） ,30~60 group （n=37） and 〉60 group （n=28）.hs-CRP and PCT levels were determined and compared between groups and correlated with Gensini score. Results PCT and hs-CRP levels of CHD patients were significantly higher than those of control group （P〈0.05）. At the same time, PCT and hs-CRP levels increase gradually with the increase of Gensini score, with a correlation index of 0.88 and 0.90 （P〈0.05）, respectively. Conclusions PCT and hs-CRP levels are positively associated with the degree of atherosclerotic lesions. Combined detection of PCT and hs-CRP can early diagnose CHD caused by coronary artery atherosclerosis.

关 键 词：降钙素原 超敏C反应蛋白 冠状动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]