^(125)I粒子植入犬胃壁组织放射性损伤的实验研究  

Radioactive Injury to Stomach Tissue after ^(125)I Seed Implantation in Beagle Dogs

作　　者：鞠再双[1] 王林[2] 李建新[2] 王若雨[1] 李响[1] 吴忠[1] 

机构地区：[1]大连大学附属中山医院肿瘤科,大连116001 [2]大连大学附属中山医院胸外科,大连116001

出　　处：《中国微创外科杂志》2014年第5期468-471,共4页Chinese Journal of Minimally Invasive Surgery

摘　　要：目的探讨犬胃壁植入125I粒子后组织的放射性损伤。方法 4只比格犬术中在胃体部植入125I粒子(活度0.5 mCi,半衰期60.2 d)6枚,设计成平行两排,行距1.0 cm,每颗粒子间距1.0 cm,植入后CT扫描(层距2 mm),并以粒子外边缘为边界勾画感兴趣区域(region of interest,ROI),进行术后剂量验证,然后分别在1、2、3、4个半衰期时处死取材,主要观察大体标本,光镜下细胞组织学变化,电镜超微结构等变化。结果比格犬胃壁植入125I放射性粒子在2个半衰期后出现放射性损伤最重,经过3个半衰期后损伤开始修复,4个半衰期后损伤已经固定并更进一步修复。结论比格犬胃壁合理分布植入125I放射性粒子是安全可靠的。Objective To investigate the stomach wall radiation damage after implantation of ^125I seeds. Methods Four Beagle dogs were intraoperatively implanted 6 ^125I seeds in gastric body. The seeds were designed to distribute parallelly in two rows with 1.0 cm between two seeds and 1.0 cm between two rows. The activity of ^125I seeds was 0.5 mCi and half-life was 60.2 days. After implantation, we employed CT scan （2 mm between each layer） , and delineated the region of interest （ROI） by the outer edge of the boundary particle outline for postoperative dose verification, and dogs were sacrificed at 1, 2, 3, 4 half-lives respectively. We mainly observed gross specimen by naked eyes, cell histological changes under optical microscope, and ultrastructural changes under electron microscopy. Results The radioactive damage occurred most severely after two half-lives since ^125I seeds＇ implantation in stomach wall; after three half-lives, the injury began to recover and after four half-lives, the damages did not expand and were further repaired. Conclusion Reasonable distribution and implantation of ^125I seeds in Beagle dogs stomach wall is safe and reliable.

关 键 词：^125I粒子 近距离治疗 胃 放射性损伤 

分 类 号：R818[医药卫生—放射医学]