The polyadenylation code:a unified model for the regulation of mRNA alternative polyadenylation  

多腺苷酸化之密码:调解mRNA可变聚腺苷酸化的统一模型(英文)

作　　者：Ryan DAVIS Yongsheng SHI 

机构地区：[1]Department of Microbiology and Molecular Genetics, School of Medicine, University of California,Irvine,Irvine,CA 92697,USA

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2014年第5期429-437,共9页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the National Institutes of Health (NIH) (No.R01 GM090056),USA

摘　　要：The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3＇ ends through a process called mRNA alternative polyadenylation （APA）. Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation.真核生物的大部分基因都通过可变聚腺苷酸化(APA)而产生多种不同的mRNA 3'端。近期的研究表明,可变聚腺苷酸化在组织发展中被动态调节,并且会受环境刺激而自动调节。现有文献中表述了多种调节机制。本文整合所有现有的调节机制模型,进而提出一个综合的统一模型。这个模型不仅概括了已知的研究结果,而且为未来的研究提供了一个预测可变聚腺苷酸化的方法。最后,我们讨论已知和假设的可变聚腺苷酸化带来的功能。

关 键 词：MRNA Alternative polyadenylation （APA） Polyadenylation site （PAS） 

分 类 号：Q75[生物学—分子生物学]