艾滋病并发皮肤T细胞淋巴瘤  

A case of cutaneous T cell lymphoma in patient with AIDS

作　　者：张凡[1] 张艳[2] 刘宝岳[3] 左杏果[4] 涂平[5] 邝捷[1] 

机构地区：[1]北京积水潭医院皮肤科,北京100035 [2]新疆医科大学第五附属医院眼科,新疆乌鲁木齐830011 [3]北京积水潭医院病理科,北京100035 [4]北京积水潭医院血液科,北京100035 [5]北京大学第一医院皮肤科,北京100038

出　　处：《临床皮肤科杂志》2014年第6期359-361,共3页Journal of Clinical Dermatology

摘　　要：报告1例艾滋病并发皮肤T细胞淋巴瘤。患者男,46岁。因全身泛发多数红色丘疹、结节5个月,伴瘙痒就诊。组织病理检查提示真皮浅层表现为以淋巴细胞为主的浸润,毛囊附属器周围淋巴细胞浸润,部分细胞核大、异形;免疫组化染色报告CD3、CD45RO抗体阳性,CD20、多发性骨髓瘤原癌基因(MUM)1、CD138抗体阴性。HIV抗体初筛试验及确证试验均阳性。T细胞亚群CD4^+计数126个/μL,CD8计数840个/μL,CD4/CD8比值0.15。A case of cutaneous T cell lymphoma in patient with AIDS is reported. A 46-year-old man presented with multiple red papules and nodules on the trunk and limbs for 5 months. Histopathology of the skin lesion revealed lymphocytic infiltration in the superficial dermis and the hair follicles. Atypical cells with large nucleus were present. Immunohistochemieal staining demonstrated strongly positive for CD3, CD45RO and negative for CD20,MUM-1 and CD138. HIV antibody screening test and confirmatory test were positive. CD4＋T and CD8＋T cell counts were 126/μL and 840/μL, respectively. CD4/CD8 ratio was 0.15.

关 键 词：艾滋病 T细胞淋巴瘤 皮肤 

分 类 号：R512.91[医药卫生—内科学] R730.263[医药卫生—临床医学]