乌司他丁对早期烧伤患者全身炎症反应综合征及多器官功能障碍综合征的影响  

Effects of ulinastatin on systemic immune response syndrome and multiple organ dysfunction syndrome in burn patients

作　　者：李沫[1] 

机构地区：[1]东北林业大学医院皮肤科,黑龙江哈尔滨150040

出　　处：《中国急救医学》2014年第6期518-520,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的 研究乌司他丁对早期烧伤患者全身炎症反应综合征（SIRS）及多器官功能障碍综合征（MODS）的影响.方法 选择哈尔滨医科大学附属第一、二医院108例烧伤患者为研究对象,将其随机分成对照组（n=54）与研究组（n=54）.对照组实施急救处理（包括常规补液、抗感染及抗休克等治疗）;研究组在实施急救处理的基础上给予200 kU乌司他丁静脉点滴治疗.比较分析两组的治疗效果.结果 研究组患者治疗后肝、肾功能均优于对照组（P＜0.05）,研究组患者的MODS及SIRS的发生率均低于对照组（P＜0.05）.结论 对早期烧伤患者采用乌司他丁进行临床治疗,可以提高患者的生存率,降低烧伤患者NODS及SIRS的发生率.Objective To investigate the effect of ulinastatin on multiple organ dysfunction syndrome （MODS） and systemic immune response syndrome （SIRS） in burn patients with during early stage treatment.Methods 108 cases of burn patients who admitted in Affiliated Hospitals of Harbin Medical University were randomly divided into the control group （54 cases） and study group （54cases）.The control group was access to first aid treatment （including conventional fluid infusion,anti infection and anti shock treatment.The study group accepted first aid treatment plus ulinastatin intravenously.Comparative analysis of the treatment was done between the groups.Results The liver,kidney functions of study group were better than those of the control group （P ＜ 0.05）.The incidence of MODS and SIRS was lower in the study group than that the control group （P ＜ 0.05）.Conclusion Early treatment with ulinastatin in burn patients can improve the survival rate,reduce the incidence of systemic inflammatory response syndrome efficiently.

关 键 词：烧伤 早期处理 乌司他丁 多器官功能障碍综合征(MODS) 全身炎症反应综合征(SIRS) 急救处理 

分 类 号：R59[医药卫生—内科学]