α-硫辛酸治疗糖尿病神经源性膀胱39例  

Clinical effect of α-lipoic acid in the treatment of diabetic neurogenic bladder: a report of 39 cases

作　　者：姜熙[1] 曹志刚[1] 罗勇[2] 陈其超[1] 

机构地区：[1]南京医科大学附属南京医院泌尿外科,江苏南京210006 [2]南京医科大学附属南京医院内分泌科,江苏南京210006

出　　处：《蚌埠医学院学报》2014年第5期583-584,共2页Journal of Bengbu Medical College

基　　金：南京医学发展基金资助项目(YKK11125)

摘　　要：目的:观察α-硫辛酸治疗糖尿病神经源性膀胱(DNB)的临床疗效。方法:将39例DNB患者随机分为治疗组20例和对照组19例,2组均给予糖尿病基础治疗,其中治疗组还给予α-硫辛酸治疗2周,对比治疗前后2组患者膀胱残余尿量差异。结果:治疗2周后,治疗组和对照组患者膀胱残余尿量均较治疗前均减少(P<0.01和P<0.05),且治疗组治疗后膀胱残余尿明显少于对照组(P<0.01),治疗组有效率明显高于对照组(P=0.00)。结论:α-硫辛酸治疗DNB效果显著,值得临床推广应用。Objective： To investigate the effect of α-lipoic acid on diabetic neurogenic bladder（ DNB）. Methods： Thirty-nine patients with DNB were randomly divided into treatment group（ n = 20） and control group（ n = 19）. Both groups received the common therapy for diabetes,and the treatment group were administered α-lipoic acid at the dose of for a 2-week course in addition. The changes of the patients＇ residual urine volume were compared between the two groups. Results： After 2 weeks of medication,the treatment group and the control group both showed a decreased residual urine volume as compared with that before the treatment（ P〈0. 01 and P〈 0. 05）;the treatment group had a more obviously decreased residual urine volume than the control（ P〈0. 01）. The total efficacy of the treatment group was significantly better than that of the control group（ P = 0. 00）. Conclusions： α-lipoic acid can significantly decrease the residual urine volume in patients with DNB and is worthy to be popularized.

关 键 词：糖尿病神经源性膀胱 Α-硫辛酸 残余尿量 氧化应激 

分 类 号：R694.5[医药卫生—泌尿科学]