野山杏总黄酮对高血脂大鼠降血脂及抗氧化作用的研究  

Study on the antiatheroscloresis and antioxidant activities of total flavonoids from wild apricot in hyperlipoidemic model rats

作　　者：阿依姑丽.艾合麦提 戴小华[1] 张华[1] 帕尔哈提.柔孜 

机构地区：[1]新疆农业大学食品科学与药学学院,乌鲁木齐830052

出　　处：《西北药学杂志》2014年第3期258-261,共4页Northwest Pharmaceutical Journal

基　　金：新疆维吾尔自治区高校科研计划科学研究重点项目(编号:XJEDU2009I12)

摘　　要：目的测定野山杏果肉中的总黄酮含量,研究野山杏总黄酮(total flavonoids from wild apricot,TFWA)对高血脂大鼠的降血脂作用和抑制肝脏脂质过氧化的能力。方法采用紫外分光光度法,测定野山杏总黄酮的含量;在建立大鼠高脂血症模型的基础上,每天灌胃不同剂量的TFWA,连续预防给药8周,观察TFWA对高血脂大鼠血清中三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等血脂水平和肝脏中脂质过氧化产物丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)的活性等抗氧化能力的影响。结果①野山杏总黄酮(TFWA)的含量为269.7mg·g-1;②TFWA的高低剂量组较高脂模型组可明显降低肝脏系数(P<0.001)、TC的水平(P<0.001)和TG的水平(P<0.01,P<0.05),TFWA的高剂量对LDL-C水平较高脂模型组可明显降低(P<0.01),对HDL-C的水平可明显升高(P<0.01);③TFWA的高低剂量组较高脂模型组显著降低肝脏中的MDA含量(P<0.01),TFWA的高剂量组较高脂模型组明显升高肝脏中SOD和GSH-Px的含量。结论 TFWA可降低高血脂大鼠的血脂,可减少肝脏损伤,抑制肝脏脂质过氧化过程,并且具有一定的剂量依赖性。Objective To determine the contents of the total flavonoids from wild apricot （TFWA） and investigate the effects of TF-WA on blood lipid and antioxidation ability in hyperlipoidemic model rats .Methods The total content of TFWA was determined . The hyperlipidemia rats were orally treated with different doses of TFWA per day continually for 8 weeks ,and TG ,TC ,LDL-C , HDL-C ,MDA ,GSH-Px and SOD levels were monitored .Results ①Contents of TFWA was 269 .7 mg · g -1 .②TFWA could ob-viously decrease the liver coefficient and the content of TC ,TG ,LDL-C and increase the serum content of HDL-C in hyperlipoi-demia rats .③TFWA lowered the level of MDA and raised the activity of SOD and GSH-Px in liver tissue .Conclusion TFWA could decrease the blood lipid level and prevent the lipid peroxidation damage in hyperlipidemia rats .

关 键 词：野山杏总黄酮 高血脂 抗氧化活性 

分 类 号：R965[医药卫生—药理学]