N-(4-烯丙基氧基-3-甲氧基苄基)-N-烷基磺酰胺类化合物的合成及其除草活性  

Synthesis and Herbicidal Activity of N-(4-Allyloxy-3-methoxy-benzyl)-N-alkyl Sulfonamides

作　　者：袁莉萍[1] 沈晓霞[1] 吕冬华[1] 胡军[1] 沈宙[1] 张一宾[1] 

机构地区：[1]上海市农药研究所,上海200032

出　　处：《农药》2014年第6期402-404,共3页Agrochemicals

基　　金："十二五"国家科技支撑计划项目(2011BAE06B004-14)

摘　　要：[目的]为在新农药创制工作中,寻找高活性化合物。[方法]以香草醛为起始原料,经烷基化、缩合、还原、磺酰胺化4步反应,设计并合成了21个未经文献报道的N-(4-烯丙基氧基-3-甲氧基苄基)-N-烷基磺酰胺类化合物,其化学结构经核磁共振氢谱确证,并对合成的化合物进行了室内杀虫、杀菌、除草生物活性的筛选。[结果]初步的生物活性表明,该类化合物具有良好的除草活性,质量浓度为250 mg/L时,化合物C9、C10、C11、C15、C16、C17、C19、C21对苋菜的抑制率达100%。[结论]该类化合物值得进一步研究。[Aims] The paper aims to find new compounds with highly bioactivity. [Methods] 21 Novel compounds of N-（4-allyloxy-3-methyoxy-benzyl）-N-alkyl sulfonamides were designed and synthesized from the starting material of vanillic aldehyde. All the compounds were bioassayed against insect, fungi and herb. [Results] The structures of all compounds were confirmed by ~H NMR. The preliminary assays showed that some compounds exhibited significant herbicidal activity. The inhibition rate of C9, C10, C11, C15, C16, C17, C19 and C21 to the Ambrosia tricolor reached 100% at the concentration of 250 mg/L. [Conclusions] It＇s worthy to further study this kind of compounds.

关 键 词：磺酰胺 合成 除草活性 

分 类 号：TQ457[化学工程—农药化工]