鼠神经生长因子联合甲钴胺及红外线治疗带状疱疹后遗神经痛的疗效观察  

Efficacy Observation of Mice Nerve Growth Factor Combined with Methylcobalamin and Infrared Therapy in the Treatment of Post Herpetic Neuralgia

作　　者：黄忠奎[1] 丁钰[1] 陈平[2] 

机构地区：[1]绵阳市中心医院皮肤科,四川绵阳621000 [2]绵阳市中心医院口腔科,四川绵阳621000

出　　处：《中国药房》2014年第22期2067-2068,共2页China Pharmacy

摘　　要：目的:观察鼠神经生长因子联合甲钴胺及红外线治疗带状疱疹后遗神经痛的疗效。方法:按随机对照原则将165例持续疼痛1个月以上的带状疱疹后遗神经痛患者,分为A、B、C组,各55例,分别给予甲钴胺、鼠神经生长因子、鼠神经生长因子联合甲钴胺治疗。3组患者每天均予以红外线照射皮损,疗程均为21 d。治疗中采用视觉模拟评分法观察止痛时间和止痛效果。结果:治疗3周后,A、B、C组的总有效率分别为81.82%、87.27%、98.18%,C组总有效率高于A、B组(P<0.05);A、B、C组疼痛完全消失时间分别为(20.35±1.99)d、(18.00±1.80)d、(13.98±1.46)d,C组明显短于A、B组(P<0.01)。结论:鼠神经生长因子联合甲钴胺及红外线治疗带状疱疹后遗神经痛效果显著,优于单独应用一种药物。OBJECTIVE： To observe the clinical efficacy of mice nerve growth factor （NGF） combined with methylcobalamin and infrared therapy in the treatment of post herpetic neuralgia. METHODS： According to randomized controlled trial, 165 patients with pot herpetic neuralgia and persistent pain for more than 1 month were divided into group A, B and C with 55 cases in each group. They were given mecobalamin, mice NGF, mice NGF combined with mecobalamin, respectively. 3 groups were given infrared radiation on lesions. Treatment course lasted for 21 d. Visual analogue score method was used to observe the analgesic time and effect. RESULTS： After 3 weeks of treatment, the total effective rates of 3 groups were 81.82%, 87.27% and 98.18%, and that of group C was higher than that of group A and B （P〈0.05）. The time of pain disappearing in 3 groups were （20.35 ± 1.99） d, （ 18.00 ± 1.80） d and （ 13.98 ± 1.46） d; that of group C was significantly shorter than that of group A and B （P〈0.01）. CONCLUSIONS： The mice NGF combined with mecobalamin and infrared therapy is significantly effective for post herpetic neuralgia, and it is better than the effect of single drug.

关 键 词：鼠神经生长因子 甲钴胺 带状疱疹后遗神经痛 

分 类 号：R986[医药卫生—药品] R969.4[医药卫生—药学]