老年人增龄变化对臂踝脉搏波传导速度影响的临床研究  

Clinical research on the influence of aging to baPWV in the elderly

作　　者：刘珍丽[1] 季振中[1] 王桦[1] 马春薇[1] 梁丽珍[1] 

机构地区：[1]武汉大学中南医院综合医疗科,430071

出　　处：《中华临床医师杂志（电子版）》2013年第10期30-32,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：湖北省自然科学基金(2010CDB06002)

摘　　要：目的探讨老年人群增龄变化对臂踝动脉脉搏波传导速度（baPWV）及衰老过程中动脉管壁器质性改变和动脉僵硬度的影响。方法使用无创全自动动脉硬化检测仪对本院综合医疗科1114例住院老年人进行臂踝动脉baPWV和踝臂指数（ABI）的检测，评估动脉硬化程度。1114例中剔除因动脉阻塞不能评估动脉僵硬度的34例，对剩余1080例老年人进行统计分析。1080例中男775例，女305例，按不同年龄段分为三组：Ⅰ组60—69岁为年轻老年组304例；Ⅱ组70—79岁为老年组371例；Ⅲ组80-94岁为高龄老年组405例。检测时患者处于安静和放松状态，所测数据与同年龄同性别标准值进行比较分析。结果三组老年人中，baPWV超标人群所占比例是随年龄升高而升高的，Ⅰ组304例中，轻度硬化71例（23．36％），中度硬化50例（16．45％），重度硬化38例（12．50％）。Ⅱ组371例中，轻度硬化121例（32．61％），中度硬化94例（25．34％），重度硬化87例（23．45％）。Ⅲ组405例中，轻度硬化106例（26．17％），中度硬化149例（36．79％），重度硬化131例（32．35％）。提示动脉硬化与增龄性因素有关（x^2=20．006，P〈0．001）。根据相对危险度的计算，与I组相比，Ⅱ组人群发生动脉硬化的风险是Ⅰ组的1．56倍，Ⅲ组人群发生动脉硬化的风险是Ⅰ组的1．82倍。Logistic回归显示，年龄、HbA1c、TC和TG是动脉硬化发生的显著性影响指标，其中，增龄因素比其他因素在动脉硬化的发生过程中，起到了更主要的影响。结论无创全自动动脉硬化检测仪检测老年人baPWV反映大动脉僵硬度随增龄变化加重，baPWV是老年人群心脑血管疾病发生风险的有效评价指标。Objective To explore the artery pulse wave velocity （baPWV）variation among different age stages and influence of organic artery wall changes to its＇ stiffness during the aging process. Methods PWV and ankle arm index（ABI） were detected for 1114 elder inpatients with noninvasive automatic arteriosclerosis detector, to eyaluate the artery stiffness. Exclude 34 cases with artery obstruction for which cannot evaluate the artery stiffness, left 1080 cases for further analysis. There were 775 males and 305 females in the included subjects, further divided into three groups according to the age. The young elderly group were defined as group Ⅰ （ between 60-69 years, 304 cases） ,the elderly group were defined as group Ⅱ （between 70-79 years,371 cases）, the old elderly group were defined as group Ⅲ （between 80-94 years,405 cases）. All patients were detected with relax and quiet, the detected data were compared with standard values of the same age and sex. Results Accordingly, the proportion of patients which＇had over standard baPWV was increased by aging. There were 71 cases （23.36%）of mild arteriosclerosis,50 cases（ 16. 45% ）of moderate arteriosclerosis and 38 cases（ 12. 50% ）of severe arteriosclerosis in group Ⅰ ;121 cases （32. 61% ）of mild arteriosclerosis ,94 cases（25.34% ）of moderate arteriosclerosis and 87 cases（23.45% ）of severe arteriosclerosis in group Ⅱ ; 106 cases （ 26. 17% ） of mild arteriosclerosis, 149 cases （ 36. 79% ） of moderate arteriosclerosis and 131 cases（32. 35% ） of severe arteriosclerosis in group Ⅲ ,indicated that the stiffness of artery was associated with aging（ x^2 = 20. 006, P 〈 0. 001 ）, and compared with group Ⅰ , the relative risk was 1.56 times in group Ⅱ, and 1.82 times in group m. According to logistic regression, aging, HbAlc, TC and TG were significant indexes for stiffness of artery, and among these, aging was more important. Conclusion Detection of elderly PWV with noninvasive automatic arteriosclerosis

关 键 词：脉搏波传导速度 增龄变化 动脉僵硬度 

分 类 号：R592[医药卫生—老年医学]