5-HT_(1A)受体参与学习记忆的分子机制研究进展  

Research Progress of Molecular Aspects of 5-HT1A Receptor in Learning and Memory

作　　者：郭瑞[1] 那杰[1] 白旭[1] 王丹[1] 刘卫娜[1] 

机构地区：[1]沈阳师范大学化学与生命科学学院,辽宁沈阳110034

出　　处：《现代生物医学进展》2014年第12期2390-2393,共4页Progress in Modern Biomedicine

基　　金：辽宁省教育厅基金项目(LS2010151);沈阳师范大学实验中心主任基金项目(SY200907)

摘　　要：5-HT(五羟色胺)能神经元是起源最早的神经元之一,在传统的神经元形成前,成长中的轴突就可释放5-HT,并且通过5-HT的各种亚型受体来实现不同的功能。近年来,随着5-HT、5-HTRs(五羟色胺受体)的基因克隆及5-HT受体选择性激动剂和拮抗剂的研究发展,5-HT系统在学习记忆中的作用越发明确,许多研究结果表明:5-HT系统在记忆的巩固、短时程记忆(STM)及长时程记忆(LTM)中起重要作用,5-HT1A受体更是在非脊椎动物及哺乳动物的脑中都高度表达,并通过相似的信号转导途径参与学习与记忆的形成和巩固。本文将介绍5-HT1A受体、5-HT1A受体激动剂、5-HT1A受体拮抗剂及其与学习记忆的联系,重点综述5-HT1A受体参与学习记忆的信号转导途径研究进展,讨论5-HT1A受体参与学习记忆的可能性分子神经生物学机制。Serotonergic neurons are among the earliest neurons to be generated,and 5-HT is released by growing axons before conventional synapses are established.Serotonin signaling is mediated by 14 receptor subtypes to realize different functional.In recent years,after the cloning and characterization of 5-HT,5-HTRs,and the resultant development of selective agonist and antagonist compounds,our understanding of the role of serotonin systems in learning and memory has improved.Many researches suggests that serotonin systems play a role in memory consolidation,short-（STM） and long-term memory（LTM）.That 5-HT1Areceptor is densely expressed in brain regions is associated with learning and memory,both in invertebrate and mammalian species,by the similar signal transduction pathway.This review will introduce the relation between 5-HT1Areceptor,5-HT1Areceptor agonists,5-HT1Areceptor antagonists and learning and memory.Especially review the research progress of 5-HT1Areceptor signal transduction pathway in learning and memory,and discuss the potential molecular neurobiology mechanism.

关 键 词：5-HT1A受体 学习与记忆 受体激动剂 受体拮抗剂 

分 类 号：Q42[生物学—神经生物学] Q965[生物学—生理学]