原发性高血压合并冠心病患者血清CRP的变化  

Changes and clinic significance of serum C-reactive protein in patients with coronary artery disease and hypertension

作　　者：王淑琴[1] 段霄燕 任晓兰[1] 欧立[1] 刘兴德[2] 邹秋富 陈娟[1] 

机构地区：[1]武警四川总队医院成都分院内一科,四川成都610041 [2]贵阳医学院附属医院心内科,贵州贵阳550005 [3]武警四川总队医院马尔康医院内科,四川马尔康624000

出　　处：《现代生物医学进展》2014年第13期2504-2506,共3页Progress in Modern Biomedicine

基　　金：贵阳市科学技术计划项目((2006)筑科农字27-5);贵州省卫生厅科学技术基金项目((2006)130-6)

摘　　要：目的:探讨原发性高血压合并不同类型冠心病患者血清C-反应蛋白(CRP)的变化及其意义。方法:用全自动生化分析仪检测71例原发性高血压患者和28例健康对照组人群的血清CRP水平,所有研究对象均行选择性冠状动脉造影检查。将原发性高血压组病人根据冠脉造影检查分为单纯原发性高血压组(EH),原发性高血压合并稳定性心绞痛组(EH+SAP)、原发性高血压合并不稳定心绞痛组(EH+UAP)、原发性高血压合并心肌梗死组(EH+MI),比较各组患者血清CRP水平的差异。结果:①与对照组比较,EH组及EH合并CAD各组患者血清CRP均显著升高(P<0.05);②与EH组比较,EH+UAP和EH+MI组血清CRP水平均显著升高(P<0.01);③与EH+SAP组比较,EH+AMI组和EH+UAP组血清CRP水平均显著升高(P<0.01)。结论:冠心病合并原发性高血压患者血CRP水平与冠状动脉病变程度与斑块稳定程度存在正相关性。Objective： To study the changes and clinic significance of Serum C-reactive protein（CRP） in patients with coronary heart disease（CAD） and hypertension（EH）. Methods： CRP levels of 71 patients with hypertension（EH） was diagnosed by coronary angiography, and 28 persons without the disease（control group） were measured with automatic biochemical analysator. All the EH patients were divided into sub-groups of hypertension（EH）, hypertension with stable angina pectoris（EH＋SAP）, hypertension with unstable angina pectoris（EH＋UAP） and hypertension with acute myocardial infarction（EH＋AMI）. All patients and control group people were operated coronary angiography. Results： ①Compared with that of control group, CRP in patients with EH significantly higher than that of control group（P〈0.05）; ② Compared with that of control group, CRP in patients with EH＋SAP, EH＋UAP and EH＋AMI sinnificantly higher than that of control group（P〈0.05）; ③ Compared with that of EH group, CRP in patients with EH＋UAP and EH＋AMI were significantly higher（P〈0.01）, also, compared with that of patients with EH＋SAP, CRP in patients with EH＋UAP and EH＋AMI were markedly higher（P〈0.01）. Conclusion： There is positive correlation between level of CRP in patients with coronary artery disease and hypertension.

关 键 词：C-反应蛋白 原发性高血压 冠心病 炎症 冠状血管造影术 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]