免疫固定电泳检测对浆细胞肿瘤相关肾损害的诊断价值  

Clinical Value of the Immunofixation Electrophoresis in the Diagnosis of Plasmacytoma related renal Impairment

作　　者：杨燕[1] 范久波[1] 李智山[1] 朱宇芳[1] 莫扬[1] 

机构地区：[1]湖北省襄阳市中心医院检验科,湖北襄阳441021

出　　处：《现代生物医学进展》2014年第13期2532-2534,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨免疫固定电泳(immunofixation electrophoresis,IFE)检测对浆细胞肿瘤相关肾损害的诊断价值。方法:回顾性分析我院肾病科665例住院患者的免疫固定电泳分型结果及检出M蛋白带的患者骨髓检查结果。结果:665例肾病科患者中检出44例单克隆免疫球蛋白带,检出率6.6%,其中IgG型24例(κ型6例,λ型18例),IgA型10例(κ型6例,λ型4例),IgM型2例(均为κ型),单纯轻链κ型2例,单纯轻链λ型6例;此44例患者经骨髓检查,38例确诊为多发性骨髓瘤(multiple myeloma,MM),2例确诊为巨球蛋白血症(waldenstrom macroglobulinemia,WM),骨髓涂片中骨髓瘤细胞比例均≥10%;骨髓瘤细胞<10%的4例,诊断为意义未明单克隆免疫球蛋白血症(monoclonal gammopathy of un-determined significance,MGUS)。结论:免疫固定电泳检测可对浆细胞肿瘤相关肾损害提供重要的诊断和分型依据,值得临床应用。Objective： To investigate the Clinical value of immunofixation electrophoresis on diagnosis of plasmacytoma related renal impairment. Methods： 665 cases IFE records of patients with department of nephropathy in our hospital were retrospectively analyzed, further analyzed typing M proteins and myeloma cell ratio in bone marrow. Results： 665 cases of patients with department of nephropathy detection in 44 cases of monoclonal immunoglobulin, the detection rate 6.6%, among which IgG type 24 cases（κ type 6 cases, λ type 18cases）, IgA type 10 cases（κ type 6 cases, λ type 4 cases）, type 2 cases of IgM（both for κ type）, light chain κ type 2 cases, light chain λ type 6; The 44 patients after bone marrow examination, and 38 cases were diagnosed as MM, 2 cases were diagnosed as WM, myeloma cell percentage ≥10 %;4 cases were diagnosed as MGUS, myeloma cell percentage 10%. Conclusion： Immunofixation electrophoresis detection of plasmacytoma related renal impairment to provide important basis in diagnosis and classification, worthy of clinical application.

关 键 词：免疫固定电泳 浆细胞肿瘤 肾损害 

分 类 号：R446.6[医药卫生—诊断学]