血清NT-proBNP和h-FABP在胸部创伤患者的临床检测价值  

Clinical detection value of serum NT-proBNP and h-FABP in chest trauma patients

作　　者：徐雷 杨文东[2] 

机构地区：[1]广饶县中医院检验科,山东东营257300 [2]利津县第二人民医院,山东东营257447

出　　处：《医学检验与临床》2014年第2期20-22,28,共4页Medical Laboratory Science and Clinics

摘　　要：目的：通过检测胸部创伤患者治疗前后血清N末端B型钠尿肽原（NT-proBNP）和心脏型脂肪酸结合蛋白（h-FABP）水平变化，探讨血清NT-proBNP和h-FABP在其合并心功能及心肌细胞损害的早期检测价值。方法：选择82例胸部创伤合并心肌挫伤患者（挫伤组）和50例健康对照组为研究对象，挫伤组采用rhGH治疗。血清NT-proBNP检测采用电化学发光免疫分析（ECLIA）法，血清h-FABP检测采用双抗体夹心酶联免疫（ELISA）一步法。结果：①治疗前血清h-FABP阳性率（41.4%）显著高于NT-proBNP（29.8%）及ECG（17.7%）（P＜0.01）。②治疗前，胸部创伤合并心肌挫伤患者血清NT-proBNP 和h-FABP水平分别显著高于对照组（P＜0.01）；治疗后，两者水平均显著低于治疗前（P＜0.01），与对照组差异无统计学意义（P＞0.05）。③胸部创伤合并心肌挫伤患者血清NT-proBNP与h-FABP呈显著正相关（r=0.719，P＜0.01），相关性良好。④胸部创伤合并心肌挫伤的82例患者经rhGH治疗后，血清NT-proBNP 和h-FABP水平达正常，ECG也无异常表现，无1例死亡病例。结论：rhGH对胸部创伤合并心肌挫伤具有临床治疗作用，血清NT-proBNP和h-FABP的联合检测可早期诊断胸部创伤合并心功能及心肌细胞损害，也可观察临床疗效。Objective：Through the observation of chest trauma caused by myocardial contusion patients serum NT-proBNP and h-FABP level change, To explore serum NT-proBNP and h-FABP united in their heart function and the value of the early detection of myocardial cell damage.Methods：A total of 82 patients with chest trauma combined with myocardial contusion （contusion group） and cases of control group as the research object,contusion group using rhGH treatment. Serum NT-proBNP detection using ECLIA method, serum h-FABP detection using ELISA method.Results： Before treatment serum h-FABP positive rate （41.4%） was statistically higher than NT-proBNP （29.8%） and ECG （17.7%） （P〈0.01）. Before treatment NT-proBNP and h-FABP were significantly higher than those in the control group（P〈0.01）.After treatment level significantly（P〈0.01）, and the control group there was no significant difference in sex（P〉0.05）.Serum NT-proBNP and h-FABP is a significant positive correlation（r=0.719, P〈0.01）, and the correlation is good.82 patients after treatment by rhGH,serum NT-proBNP and h-FABP level of normal, ECG and no abnormality,no 1 deaths.Conclusions： rhGH chest trauma to merge myocardial contusion therapeutic effect,combined detection of serum NT-proBNP and h-FABP level and can be early diagnosis chest trauma combined cardiac function and myocardial cell damage,and clinical curative effect observation.

关 键 词：胸部创伤 N末端B型钠尿肽原 心脏型脂肪酸结合蛋白 心肌细胞损害 重组人生长激素 

分 类 号：R543.3[医药卫生—心血管疾病]