血清25羟基维生素D与急性冠状动脉综合征关系的临床研究  

Relationship between serum 25-hydroxy-vitamin D with acute coronary syndrome

作　　者：赵亚楠[1] 李时乐[1] 韦美玉[1] 倪燕萍[1] 徐延敏[1] 

机构地区：[1]天津医科大学第二医院心脏科,300211

出　　处：《中华临床医师杂志（电子版）》2013年第4期88-90,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨血清25羟基维生素D(25-OH-D)与急性冠状动脉综合征(ACS)的关系。方法入选符合国际心脏病的诊断和命名标准患者152例,分为正常对照组36例,稳定型心绞痛组35例,ACS组81例,其中ACS组分为不稳定型心绞痛组40例,急性心肌梗死组41例。采用酶联免疫法对入选对象进行血清25-OH-D、基质金属蛋白酶9(MMP-9)水平的测定。结果 ACS组血清25-OH-D水平显著低于SAP组和正常对照组[(225.78±38.48)ng/Lvs.(325.00±42.74)ng/L,(339.69±35.30)ng/L,P<0.01];急性心肌梗死组血清25-OH-D水平低于不稳定型心绞痛组[(219.75±31.53)ng/Lvs.(231.97±44.04)ng/L,P<0.01],正常对照组与稳定型心绞痛组血清25-OH-D水平无统计学差异(P>0.05)。ACS组血清MMP-9水平显著高于稳定型心绞痛组和正常对照组[(563.36±48.18)ng/Lvs.(341.39±46.23)ng/L,(330.03±48.06)ng/L,P<0.01];急性心肌梗死组血清MMP-9水平高于不稳定型心绞痛组[(598.88±29.34)ng/Lvs.(526.95±34.56)ng/L,P<0.01],正常对照组与稳定型心绞痛组血清MMP-9水平无显著统计学差异(P>0.05)。结论血清25-OH-D在ACS发生发展过程中呈降低趋势,其变化可能与参与斑块的炎症反应有关,在ACS发病中起一定作用。Objective To investigate the relationship of the serum 25-hydroxy vitamin D with acute coronary syndrome（ACS）. Methods 152 patients who conformed to standard were chosen. The patients were divided into ACS group（ n = 81 ）, SAP group（ n = 36 ）and NC group （n = 35 ）. By clinical conditions, we also divided ACS group into AM1 group（ n = 41 ）and UAP group （n = 40）.The level of 25-hydroxy Vitamin D, MMP-9 were measured by ELISA in every group. Results The serum level of 25-hydroxy vitamin D was significantly lower in ACS group than in SAP group, control group [ （ 225.78 ± 38.48 ） ng/L vs. （ 325.00 ± 42. 74 ） ng/L, （ 339. 69 ± 35. 30 ） ng/L, P 〈 0. 01 ]. The serum level of 25-hydroxy vitamin D was lower in AMI group than in UAP group [ （219. 75 ± 31.53 ）ng/ L vs. （231.97 ± 44. 04 ）ng/L,P 〈 0.01 ]. No significantly statistics significance was found between SAP group and control group（P 〉 0. 05 ）. The serum level of MMP-9 was significantly higher in ACS group than in SAP group, control group[ （563.36 ±48.18） ng/L vs. （341.39 ±46. 23） ng/L, （330. 03 ±48. 06） ng/L,P 〈0. 01 ]. The serum leyel of MMP-9 was higher in AMI group than in UAP group [ （ 598. 88 ± 29. 34 ） ng/L vs. （ 526.95 ± 34. 56 ） ng/L, P 〈 0. 01 ]. No significantly statistics significance was found between SAP group and control group （ P 〉 0. 05 ）. Conclusions The serum 25-hydroxy vitamin D and MMP-9 level was negatively correlated in patients with acute coronary syndrome. The serum 25-hydroxy vitamin D was reduced in ACS,its change may be related with the plaque inflammatory, and may play an important role in the athogenesis mechanism of ACS.

关 键 词：急性冠状动脉综合征 基质金属蛋白酶9 25羟基维生素D 

分 类 号：R541.4[医药卫生—心血管疾病]