伴t（8；21）易位急性髓细胞白血病实验室及临床特点分析  

Analysis on the Characteristics of Clinical and Laboratory in t（8；21） Acute Myeloid Leukemia Patients

作　　者：沈军[1] 马亮[1] 钟明华[2] 韩呈武[1] 曹永跃[1] 湛玉良[1] 曹永彤[1] 

机构地区：[1] 中日友好医院检验科,北京100029 [2] 中日友好医院血液科,北京100029

出　　处：《现代检验医学杂志》2014年第2期130-133,共4页Journal of Modern Laboratory Medicine

摘　　要：目的 分析伴t（8；21）易位急性髓细胞初诊白血病患者FAB分型、血常规、骨髓细胞形态学、细胞遗传学及临床预后特点.方法 20例患者为中日友好医院2004年-2011年按WHO标准确诊的急性髓细胞白血病（AML）患者,血常规采用XE-2100全自动分析仪分析;骨髓细胞形态学检测对骨髓涂片进行瑞氏-姬姆萨染色,显微镜计数细胞;细胞遗传学检测为常规培养骨髓细胞,采用G显带技术对染色体核型进行分析.结果 伴t（8；21）易位AML患者中55％（11/20）患者外周血白细胞升高,20％（4/20）患者白细胞减低,所有患者均伴血小板减低.85％（17/20）患者骨髓涂片中可见奥氏小体.根据FAB分型,20例患者中15％（3/20）诊断为MDS-RAEB,20％（4/20）为MDS-RAEBt,55％（11/20）为AML-M2,10％（2/10）为AML-M4.55％（11/20）患者为单纯t（8；21）易位,45％（9/20）患者为t（8；21）易位同时伴有其它异常,其中伴性染色体丢失占所有患者35％（7/20）,伴有9q-占所有患者的10％（2/20）.82.4％（14/17）患者能达到完全缓解.结论 伴t（8；21）易位AML患者可见于FAB分型的不同亚型,主要见于AML-M2.t（8；21）患者常伴有附加异常,以性染色体丢失常见.t（8；21）易位患者疗效较好.Objective To study the features of the FAB subgroups, blood routine, morphologic, cytogenetic and prognosis in deno acute myeloid leukemia（AML） patients with t（8;21）. Methods 20 patients from 2004 to 2011 were diagnosed by WHO criterion,blood routine were analyzed by XE-2100 auto analyzer. Morphologic were stained by Wright＇ s-Giemsa,and counted by microscope. The chromosome was prepared with brief culture of bone marrow,and the karyotype was analyzed by G banding technique. Results The number of white cell in 55 % of the AML patients with t（8;21） were higher than nor real,and 20 % patients were lower than normal, the platelet count of all the patients were lower. Auer body could be detected in 85 % patients （17/20）. According FAB subgroups, 15% （3/20） patients could be diagnosed as MDS-RAEB, 20% （4/20） patients were MDS-RAEBt,55%（11/20） were AML-M2,and 10%（2/10） were AML-M4.55%（11/20） patients were t（8; 21） without other additional aberrations, 45 % （9/20） patients were t （8 ; 21） with other additional aberrations. Sex chromosome losses were found in 35%（7/20） patients,and 9q were found in 10%（2/20） patients. 82.4%（14/17） patients could achieve complete remission. Conclusion The acute myeloid leukemia patients with t（8;21） could be detected in different sub groups according FAB,mainly distributed in AML-M2. The t（8;21） AML patients often had many other additional aberrations,and sex chromosome losses were common. The efficacy of t（8;21） patients were better.

关 键 词：t(8 21) 急性白血病 染色体 形态 疗效 

分 类 号：R551[医药卫生—血液循环系统疾病]