左氧氟沙星致低血糖  

Hypoglycemia induced by levofloxacin

作　　者：周璇[1] 卢敏[1] 

机构地区：[1]温州医科大学附属第二医院药学部,325027

出　　处：《药物不良反应杂志》2014年第2期122-123,共2页Adverse Drug Reactions Journal

摘　　要：1例57岁女性患者因直肠黑色素瘤切除术后感染,给予左氧氟沙星注射液0.2 g/100 ml静脉滴注,2次/d,用药约20 min时患者出现乏力、盗汗、心悸等症状,急查血糖,为2.7 mmoL/L。立即停用左氧氟沙星,静脉滴注10%葡萄糖500 ml,同时进食糖果,上述症状缓解。次日,再次静脉滴注左氧氟沙星约10 min后上述症状复现,即时血糖2.8 mmol/L。再次停用左氧氟沙星并给予对症治疗,症状缓解。改用其他抗生素治疗,患者感染得到控制,未再出现低血糖反应。A 57-year-old woman with postoperative infection of rectal melanoma received an Ⅳ infusion of levofloxacin 0.2 g/100 ml twice daily.She developed weakness,hyperhidrosis,and palpitation 20 minutes after Ⅳ infusion.Laboratory examination showed that blood glucose was 2.7 mmol/L.Levofloxacin was discontinued immediately.She was given an Ⅳ infusion of 10% glucose 500 ml and candy.Her symptoms were mitigated.She was given an Ⅳ infusion of levofloxacin injection on the next day.The symptoms mentioned above recurred 10 minutes later.Laboratory examination showed blood glucose was 2.8 mmol/L.Levofloxacin was discontinued immediately and the symptomatic treatment was given again.Her hypoglycemia symptoms relieved.After switching to other antibiotics,her infection was under control and the hypoglycemic reaction did not occur again.

关 键 词：左氧氟沙星 低血糖 

分 类 号：R595.3[医药卫生—内科学]