高血压病患者心-踝血管指数与血管内皮功能相关性研究  

Relationship between cardio-ankle vascular index and endothelial function in patients with hypertension

作　　者：聂志华[1,2] 许顶立[1] 郑侨克 黄蕾[3] 罗浩[3] 赖冬[3] 熊润清 

机构地区：[1]南方医科大学附属南方医院心内科,广州510515 [2]厦门市海沧医院心内科,福建厦门361026 [3]厦门市第二医院心内科

出　　处：《临床心血管病杂志》2014年第5期399-401,共3页Journal of Clinical Cardiology

基　　金：厦门市科技指导项目(No:2011S0434)

摘　　要：目的:观察心-踝血管指数(CAVI)与血浆内皮微颗粒和血流介导的内皮依赖性肱动脉血管舒张功能(FMD)的相关性。方法:入选高血压患者48例,颈动脉血管超声检查无动脉粥样斑块且颈动脉内膜厚度(CIMT)<0.9mm。使用动脉硬化检测仪检测CAVI,血管超声检测FMD,流式细胞仪检测血浆血管内皮微颗粒。结果:CAVI与FMD呈负相关(r=-0.327,P=0.023),与内皮微颗粒呈正相关(r=0.348,P=0.015),FMD与内皮微颗粒呈负相关(r=-0.376,P=0.008)。结论:CAVI能反映血管内皮功能异常,是反映早期动脉粥样硬化的敏感指标。Objective：To investigate the association of cardio-ankle vascular index and endothelial function in hypertensive patients.Method：A total of 48patients with hypertension[carotid intima-media thickness（CIMT） 0.9mm]were included in this study.All subjects were measured for cardio-ankle vascular index（CAVI）with a VaSeraTM VS-1000CAVI instrument.Flow-mediated dilatation（FMD）was measured by ultrasound.Fasting blood samples were sent to measure endothelial microparticles（CD31＋/CD42b）by flow cytometry.Result：Bivariate correlation analysis revealed that CAVI was significantly correlated with FMD（r=-0.327,P=0.023）,endothelial microparticles（CD31＋/CD42b）（r=0.348,P=0.015）.FMD was significantly correlated with endothelial microparticles（CD31＋/CD42b）（r=-0.376,P=0.008）.Conclusion：CAVI could reflect endothelial function,and also could be a sensitive index which reflect early arteriosclerosis.

关 键 词：高血压 心-踝血管指数 血流介导的内皮依赖性肱动脉血管舒张功能 内皮微颗粒 动脉粥样硬化 早期病变 

分 类 号：R541.4[医药卫生—心血管疾病]