凋亡抑制基因Livin和血管内皮生长因子在寻常疣和尖锐湿疣中的表达  

Expression and Significance of Anti-Apoptotic Gene Livin and Vascular Endothelial Growth Factor in Immunohistochemistry and Condyloma Acuminatum

作　　者：袁波[1] 林蕾[1] 应振毅[1] 石磊[1] 周琼艳[1] 匡志坚 

机构地区：[1]宁波大学医学院附属医院,浙江宁波315020 [2]宁波市明州医院,浙江宁波315100

出　　处：《中国皮肤性病学杂志》2014年第6期554-556,559,共4页The Chinese Journal of Dermatovenereology

基　　金：宁波大学校级课题(编号:xyy12007)

摘　　要：目的观察Livin和血管内皮生长因子(vascular endothelial growth factor,VEGF)在寻常疣以及尖锐湿疣组织中的表达情况,探讨其在人类乳头瘤病毒感染所致皮肤疾病中的意义。方法收集30例寻常疣、30例尖锐湿疣及20例正常皮肤组织标本,采用免疫组化SP法检测Livin和VEGF在该3组标本组织中的表达情况。结果尖锐湿疣、寻常疣和正常包皮组织中Livin的表达阳性率分别为83.33%,60.00%和30.00%,表达强度依次为(2+)～(3+)、(-)～(2+)和(-)～(+)。而且该3组标本组织中均表达VEGF,阳性率均为100.00%。尖锐湿疣中VEGF表达强度多数为(2+～3+),其他两组中表达强度多数为(+～2+)。三组标本组织中Livin和VEGF阳性表达率的差异均有统计学意义(P均<0.01),且CA组织中Livin与VEGF表达呈正相关(P<0.01)。结论尖锐湿疣组织中存在Livin和VEGF过表达,其过表达可能对尖锐湿疣发生发展有一定的作用。Objective The aims of present study was to determine the expression and significance of anti - apoptotic gene Livin and vascular endothelial growth factor （VEGF） in eondyloma acuminatum （CA）. Methods The expressions of Livin and VEGF were analyzed by immunohistoehemical staining with streptavidin - pemxidase （SP） in tissue specimens from 30 patients with CA, 30 patients with common warts and 20 normal human controls. Results The positive expression rates of Livin in CA, common warts and normal control were 83.33 %, 600% and 300%, respectively. The staining intensity of Livin ranged from 2 ＋ to 3 ＋ in CA lesions, negative to 2 ＋ in the common warts, and negative to 1 ＋ in controls. VEGF was expressed in all groups. The staining intensity of VEGF ranged from 2 ＋ to 3 ＋ in CA, 1 ＋ to 2 ＋ in both the common warts and normal tissues. The expression of Livin and VEGF was significantly different among three groups （P 〈0.01 ）. There is a positive correlation between the expression of Livin and VEGF in CA （ P 〈 0.01 ）. Conclusion Livin and VEGF were over - expressed in CA, suggesting their involvement in the emergence and development of CA.

关 键 词：尖锐湿疣 寻常疣 LIVIN 血管内皮生长因子 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]