TRAIL和Caspase-3在尖锐湿疣组织中的表达  

The Expression of TRAIL and Caspase-3 in Condyloma Acuminatum

作　　者：李冬芹[1] 罗杨[1] 李真真[1] 张海璐 尹光文[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《中国皮肤性病学杂志》2014年第6期570-572,共3页The Chinese Journal of Dermatovenereology

基　　金：河南省科技攻关项目(132102310517)

摘　　要：目的观察尖锐湿疣(CA)组织中肿瘤坏死因子相关凋亡诱导配体(TRAIL)和半胱氨酸蛋白酶-3(Caspase-3)的表达情况并探讨其意义。方法采用免疫组化SP法检测30例CA患者组织中和20例正常包皮组织中TRAIL和Caspase-3的表达情况,并进行相关性分析。结果 CA组织中TRAIL阳性表达率(73.33%)和表达强度(+～3+)明显高于正常包皮组织(20.00%和+～2+),差异均有统计学意义(P均<0.05)。CA组织中Caspase-3阳性表达率(60.00%)略低于正常包皮组织(65.00%),差异无统计学意义(P>0.05);但是CA组织中的Caspase-3表达强度(+～2+)低于正常包皮组(2+～3+),差异也有统计学意义(P<0.05)。CA组织中TRAIL和Caspase-3的阳性表达呈现正相关(P<0.05)。结论 CA组织中均存在TRAIL和Caspase-3异常表达,该两者可能共同参与了CA的发生和发展。Objective To explore the expression and significance of TRAIL and Caspase-3 in lesions of Condyloma Acuminatum（CA）. Methods SP immunohistochemical technique was used to examine the expression of TRAIL, Caspase-3 in 30 cases of CA tissues and 20 cases of healthy prepuce tissues. Results Both the positive expression rate and the intensity of TRAIL in CA tissues（73.33% and ＋ - 3 ＋ ） were obviously higher than that in healthy prepuce tissues （20.00% and ＋ - 2 ＋ ）. There were significant differences between the two groups（ both P 〈 0.05 ）. The positive expression rate of Caspase-3 in CA tissues（60.00% ） was a little lower than in healthy prepuce tissues （ 65.00% ） , there was no statistical difference between them （ P 〉 0.05 ） ; the intensity of Caspase-3 in CA tissues（ ＋ -2 ＋ ） was lower than in healthy prepuce tissues（2 ＋ -3 ＋ ）. There was a significant difference between two groups（ P 〈 0.05 ）. There was positively correlation between the expression of these 2 markers（P 〈 0.05 ）. Conclusion The abnormal expression of TRAIL and Caspase-3 in CA tissues may be involved in the emergence and development of CA.

关 键 词：尖锐湿疣 肿瘤坏死因子相关凋亡诱导配体 半胱氨酸蛋白酶-3 表达 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]