人亨廷顿相互作用蛋白14在1型糖尿病发病中的作用  

The effect of Huntingtin interacting protein 14 on the development of type 1 diabetes mellitus

作　　者：胡志为[1] 黄婷[1] 刘艳霞[1] 栗夏连[1] 

机构地区：[1]郑州大学第一附属医院内分泌科,河南郑州450052

出　　处：《河南医学研究》2014年第4期6-8,共3页Henan Medical Research

摘　　要：目的:探讨人亨廷顿相互作用蛋白(Huntingtin interacting protein 14,HIP14)在1型糖尿病患者血浆中表达水平的变化,并分析其与胰岛功能的关系。方法:采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测1型糖尿病组中47例1型糖尿病患者及对照组50例健康人血浆HIP14含量,分析HIP14表达水平与空腹血糖(FBG)、空腹胰岛素(FINS)及胰岛β细胞功能指数(HOMA-IS)的相关性。结果:1型糖尿病组与健康对照组相比,血浆HIP14表达水平明显下降(P<0.05)。相关分析显示血浆HIP14表达水平与FBG无明显相关性,而与FINS及HOMA-IS呈明显正相关(P<0.05)。结论:1型糖尿病患者血浆中HIP14含量明显下降,HIP14表达下调可能与胰岛素的分泌受损及糖尿病的发生有关。Objective： To investigate the expression levels of HIP14 in type 1 diabetic patients and the relationship between the expression levels of HIP14 and islet function. Methods： The expression levels of HIP14 were detected in 47 patients with type 1 diabetes （type 1 diabetes group） and 50 healthy people （ control group） by enzyme-linked immunosorbent assay （ELISA）. The relation- ship between HIP14 and fasting blood glucose（FBG） , fasting insulin（FINS） , HOMA-IS was analyzed by correlation analysis. Results ： Compared with control group, the expression levels of HIP14 in type 1 diabetes group were significantly decreased. The expression levels of HIP14 were positively correlated with FINS, HOMA-IS, but not with FBG. Conclusion： The expression levels of HIP14 in type 1 diabetic patients were lower. Decreased expression of HIP14 was correlated with the deficiency of insulin secretion and development of T1DM.

关 键 词：人亨廷顿相互作用蛋白14 1型糖尿病 胰岛素分泌 

分 类 号：R587.1[医药卫生—内分泌]