不同程度糖尿病性视网膜病变患者中央角膜厚度的分析  

Analysis of central corneal thickness in different degrees of diabetic retinopathy

作　　者：华山[1] 王继亚[1] 

机构地区：[1]东莞东华医院眼科,中国广东省东莞市523110

出　　处：《国际眼科杂志》2014年第6期1061-1063,共3页International Eye Science

摘　　要：目的:研究不同程度糖尿病性视网膜病变(DR)患者中央角膜厚度(CCT)的变化及相关性。方法:采用角膜内皮显微镜对65例130眼不同程度糖尿病性视网膜病变患者(均为2型糖尿病患者)及年龄、性别相匹配的35例70眼正常健康人进行中央角膜厚度检测,并对结果进行统计分析。结果:轻度、中度非增生期糖尿病视网膜病变(NPDR)组与对照组比较,中央角膜厚度差异无统计学意义(P>0.05),而重度NPDR组和增生期糖尿病视网膜病变(PDR)组的CCT较对照组增厚,差异有统计学意义(P<0.05);组间比较中:轻度NPDR组与重度NPDR组和PDR组比较,差异有统计学意义(P<0.05),中度NPDR组与PDR组比较,差异有统计学意义(P<0.05);且CCT随DR的程度加重而增厚,呈正相关(r=0.173,P<0.05)。结论:糖尿病性视网膜病变的中央角膜厚度随着病变加重逐渐增厚。DR患者治疗过程中,尤其是内眼手术时应特别注意保护角膜内皮,减少并发症的发生。AIM： To study central corneal thickness（CCT）and correlation in different degrees of diabetic retinopathy（DR）.METHODS： A total of 65 cases（130 eyes）with different degrees of DR and 35 normal cases（70 eyes）as the age-and gender-matched control group were examined by corneal endothelial microscope, to measure CCT and statistics RESULTS： Compared to control group, there were no significant difference of CCT both mild and medium nonproliferative diabetic retinopathy（NPDR）groups（P〉0.05）. While the CCT of severe NPDR group and proliferative diabetic retinopathy（PDR）group were thicker than control group, and the differences were statistically significant（P〈0.05）; Pairwise comparison in different degrees of DR groups： the CCT of severe NPDR and mild NPDR groups were thicker than PDR group, and the differences were statistically significant（P〈0.05）; compared to medium NPDR, the CCT of PDR was thicker（P〈0.05）; The thickness of CCT increases with severity of DR, there was positive linear correlation（r=0.173, P〈0.05）.CONCLUSION： The CCT increases with severity of DR. Taking care of protecting corneal endothelium is very important in the time of therapeutic measure, especially intraocular operation, to decrease complication.

关 键 词：糖尿病性视网膜病变 中央角膜厚度 角膜并发症 

分 类 号：R587.2[医药卫生—内分泌]