不同时间给予昂丹司琼预防小儿斜视术后恶心呕吐的临床观察  

Clinical observation of ondansetron administration at different time in preventing nausea and vomiting after pediatric strabismus surgery

作　　者：刘怀刚[1] 李晓静[1] 李建军[2] 

机构地区：[1]济南市明水眼科医院,中国山东省济南市250200 [2]山东大学齐鲁医院麻醉科,中国山东省济南市250012

出　　处：《国际眼科杂志》2014年第6期1177-1178,共2页International Eye Science

摘　　要：目的：不同时间静脉注射昂丹司琼在小儿斜视术后恶心呕吐（postoperative nausea and vomiting，PONV）中的效果观察。方法：随机选择2013-06/08在我院拟行斜视手术的患儿90例，ASAⅠ～Ⅱ级，年龄3～11岁。随机分为3组，每组30例。A组在手术开始前静脉注射昂丹司琼0.1mg/kg； B组在手术结束后静脉注射昂丹司琼0.1mg/kg； C组为对照组，不用昂丹司琼。在术后24h内观察患者恶心、呕吐的发生例数及严重程度。结果：三组患者的性别、体重、年龄、麻醉时间、氯胺酮用量各组间比较无统计学意义（P〉0.05）。A，B组的PONV发生率明显低于C组（P〈0.05），A组和B组的PONV发生率比较无统计学意义（P〉0.05）。结论：在手术前或手术结束时应用昂丹司琼可有效、安全地预防小儿斜视手术后的PONV，提高眼科手术安全性，且费用低，是一种值得推广应用的止吐方法。AIM： To observe the efficacy of ondansetron by intravenous injection at different time in preventing nausea and vomiting after pediatric strabismus surgery. METHODS： Totally 90 children aged 3-11y were randomly selected for pediatric strabismus surgery from June 2013 to August 2013 in our hospital. The ASA grade of all children were Ⅰ-Ⅱ. Children were randomly divided into three groups with 30 cases each. Group A received intravenous drip of ondansetron 0.1mg/kg before surgery. Group B received intravenous drip of ondansetron 0.1mg/kg after surgery. Group C as control group was not given ondansetron. The number and severity of nausea and vomiting were observed within 24h after surgery. RESULTS： There were no statistical significance in patients＇ gender, weight, age, duration of anesthesia, ketamine dosage and vital signs intraoperative between the three groups（P〉0.05）. The incidence rate of postoperative nausea and vomiting（PONV）of group A and B were significantly lower than group C（P〈0.05）. The incidence rate of PONV of group A and group B have no significant difference（P〉0.05）. CONCLUSION： Using ondansetron is effective and safe in preventing PONV before and at the end of the pediatric strabismus surgery, which can also improve safety and be lower cost. It is a worthy promoting antiemetic approach for eye surgery.

关 键 词：昂丹司琼 小儿斜视手术 恶心呕吐 

分 类 号：R726.1[医药卫生—儿科]