耐氟康唑念珠菌和耐伊曲康唑烟曲霉对泊沙康唑的敏感性测定  

Antifungal susceptibility testing of clinical isolates of fluconazole-resistant Candida spp. and itraconazoleresistant Aspergillus funmigates to posaconazole

作　　者：王雪洁[1,2] 万喆[1,2] 李若瑜[1,2] 刘伟[1,2] 

机构地区：[1]北京大学第一医院皮肤科 [2]北京大学真菌和真菌病研究中心皮肤病分子诊断北京市重点实验室,北京100034

出　　处：《中国真菌学杂志》2014年第2期75-78,共4页Chinese Journal of Mycology

基　　金：教育部"新世纪优秀人才支持计划"(NCET-10-0198)

摘　　要：目的：测定耐氟康唑念珠菌和耐伊曲康唑烟曲霉临床分离株对泊沙康唑的敏感性。方法参照美国临床实验室标准化研究所制定的 M27-A3和 M38-A2方案，测定从临床获得的11株耐氟康唑的念珠菌和3株耐伊曲康唑烟曲霉对泊沙康唑的 MIC 值。结果对于氟康唑耐药的念珠菌，泊沙康唑的 MIC 范围是0.125-1μg/ mL。对于伊曲康唑耐药烟曲霉，泊沙康唑的 MIC 范围是0.06-0.5μg/ mL。结论11株耐氟康唑的念珠菌和3株耐伊曲康唑烟曲霉均对泊沙康唑有效。Objective To determine the in vitro susceptibility of fluconazole（ FLU）-resistant Candida spp. and itraconazole （ITC）-resistant Aspergillus spp. to posaconazole（POS）. Methods The MICs of FLU,ITC,voriconazole（VRC）and POS were determined according to CLSI M27-A3 and M38-A2 methods in eleven isolates of Candida spp. and three isolates of Aspergillus spp. Results MICs of FLU,ITC,VRC and POS against FLU-resistant Candida spp. were 64 μg/ mL,0. 5 - 16 μg/ mL,0. 25 - 2 μg/mL and 0. 125 - 1 μg/ mL. And MICs of ITC,VRC and POS against ITC-resistant Aspergillus spp. were ﹥ 16 μg/ mL,1 - 2 μg/ mL and 0. 25 - 0. 5 μg/ mL. Conclusion POS is effective to FLU-resistant Candida spp. and ITC-resistant Aspergillus spp. in vitro .

关 键 词：耐药性 念珠菌 烟曲霉 泊沙康唑 

分 类 号：R978.5[医药卫生—药品]