多胺在微生物中的研究进展  

Recent progress of polyamines in microorganisms

作　　者：姚响文[1] 周密[1] 曹颖瑛[1] 姜远英[1] 

机构地区：[1]第二军医大学药学院新药研究中心,上海200433

出　　处：《中国真菌学杂志》2014年第2期114-118,共5页Chinese Journal of Mycology

基　　金：国家自然科学基金(81271798);国家973项目(2013CB531602)

摘　　要：多胺是一类小分子脂肪族类化合物,存在于微生物体内,其合成代谢与微生物细胞的增殖和分化密切相关,参与微生物的多种生理过程,在促进细胞分化、增殖,维持细胞膜、DNA和RNA的稳定,以及生理应激方面发挥重要作用。该文就多胺的代谢、转运以及多胺在微生物中的生理功能等方面进行综述,为多胺在微生物中的研究提供较为丰富的资料。Polyamines including putrescine,spermidine,spermine and cadaverine are polycationic molecules with hydrocarbon backbone and multiple amino groups. These subjects are essential metabolites presented in microorganisms. And polyamines involve many physiological processes of microbe,from growth to development and differentiation. Some studies found that polyamines could promote microbial cell proliferation,keep cell membrane,DNA and RNA stable,and play an important role in physiological stress, of late. This review focuses on the metabolism,transport and physiological functions of polyamines in microorganisms to provide more useful information.

关 键 词：多胺 微生物 代谢 

分 类 号：R37[医药卫生—病原生物学]