Relaxant Effects of Aike Mixture(艾可合剂) on Isolated Bladder and Prostatic Urethral Smooth Muscle of Rabbits  

作　　者：张敏建 史亚磊 程宛钧 李振伟 林湘 

机构地区：[1]People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine

出　　处：《Chinese Journal of Integrative Medicine》2014年第6期420-424,共5页中国结合医学杂志（英文版）

基　　金：Supported by the Natural Science Foundation of Fujian Province(No.2008J0092)

摘　　要：Objective： To observe the relaxant effect of Aike Mixture （艾可合剂, AKM） on isolated bladder and prostatic urethral smooth muscle of rabbits. Methods： The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed Jn a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system. The effects of AKM in combination with methoxyamine, carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. Results： AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle （r=0.831, P〈0.05）, reduced contractile wave amplitude （r=0.837, P〈0.05） and decreased contractile frequency （r=-0.917, P〈0.01）. AKM signJfJcantly inhibited the increases in smooth muscle contraction induced by methoxyamine, carbachol and CaCl2. Conclusion： AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.Objective： To observe the relaxant effect of Aike Mixture （艾可合剂, AKM） on isolated bladder and prostatic urethral smooth muscle of rabbits. Methods： The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed Jn a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system. The effects of AKM in combination with methoxyamine, carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. Results： AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle （r=0.831, P〈0.05）, reduced contractile wave amplitude （r=0.837, P〈0.05） and decreased contractile frequency （r=-0.917, P〈0.01）. AKM signJfJcantly inhibited the increases in smooth muscle contraction induced by methoxyamine, carbachol and CaCl2. Conclusion： AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.

关 键 词：Aike Mixture bladder smooth muscle urethral smooth muscle α1-adrenergic receptor M-cholinergic receptor Ca2＋ channel 

分 类 号：R965[医药卫生—药理学]