脂联素及受体变化在妊娠期糖尿病发病中的意义和相关因素  

Significance of adiponectin and its receptors in pathogenesis of gestational diabetes mellitus

作　　者：张美贞[1] 叶泉忠[2] 

机构地区：[1]衢州市人民医院体检中心,浙江省衢州市324000 [2]衢州市人民医院消化内科,浙江省衢州市324000

出　　处：《世界华人消化杂志》2014年第13期1907-1910,共4页World Chinese Journal of Digestology

摘　　要：目的:分析脂联素(adiponectin,APN)及受体变化在妊娠期糖尿病(gestational diabetes mellitus,GDM)发病中的意义和相关因素.方法:随机选取2011-06/2013-06我院接收治疗的50例妊娠期糖尿病孕妇和50例正常妊娠妇女,分成观察组和对照组,对两组孕妇空腹血糖、胰岛素等实验室指标进行对比测定,对临床数据进行回顾性分析,评价血脂联素与各项指标之间的关系.结果:观察组体质量指数(body mass index,BMI)、空腹血糖(fasting plasma glucose,FPG)、总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)、以及空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(homestasis model assessment for insulin resistance,HOMAIR)、APN为24.97 kg/m2±4.32 kg/m2,7.02mmol/L±0.63 mmol/L,5.39 mmol/L±1.29mmol/L,2.27 mmol/L±1.18 mmol/L,19.37 mU/L±6.37 mU/L,9.27 mmol/L±1.56 mmol/L,2.17mg/L±0.69 mg/L,1.31 mg/L±0.22 mg/L vs对照组BMI、FPG、TC、TG、FINS、HONAIR、APN的23.77 kg/m2±2.39 kg/m2,3.91 mmol/L±0.59 mmol/L,4.21 mmol/L±0.68 mmol/L,1.12 mmol/L±0.28 mmol/L,13.24 mU/L±5.61mU/L,3.26 mmol/L±0.51 mmol/L,3.62 mg/L±1.02 mg/L,0.11 mg/L±0.03 mg/L,统计学有意义(P<0.05);血清APN水平与孕前BMI、TG、HOMA-IR、FINS呈现明显负相关(r=-0.371,-0.459,-0.281,-0.321,P<0.01).结论:妊娠期糖尿病患者脂联素及受体变化与患者机体胰岛素抵抗密切相关,临床测定妊娠期糖尿病患者脂联素积极作用于妊娠期糖尿病诊断治疗.AIM： To analyze the significance of adiponectin （APN） and its receptors in in the pathogenesis of gestational diabetes mellitus （GDM） and the relevant factors involved. METHODS： Fifty pregnant women with GDM treated between June 2011 and June 2013 at our hospital and 50 normal pregnant women were included into an observation group and a control group, respectively. Fasting blood glucose, insulin and other laboratory indicators were retrospectively analyzed, and their relationship with serum APN was explored. RESULTS： In the observation group, body mass index （BMI）, fasting plasma glucose （FPG）, total cholesterol （TC）, triacylglycerol （TG）, fasting insulin （FINS）, homestasis model assessment for insulin resistance （HONA-IR） and APN were 24.97 kg/m2 ± 4.32 kg/m2, 7.02 mmol/L ± 0.63 mmol/L, 5.39 mmol/L ± 1.29 mmol/L, 2.27 mmol/L ± 1.18 mmol/L, 19.37 mU/L ± 6.37 mU/L, 9.27 mmol/L ± 1.56 mmol/L, 2.17 mg/L ± 0.69 mg/L and 1.31 mg/L ± 0.22 mg/L, respectively; the corresponding values in the control group were 23.77 kg/m2 ± 2.39 kg/m2, 3.91 mmol/L ± 0.59 mmol/L, 4.21 mmol/L ± 0.68 mmol/L, 1.12 mmol/L ± 0.28 mmol/L, 13.24 mU/L ± 5.61 mU/L, 3.26 mmol/L ± 0.51 retool/ L, 3.62 mg/L ± 1.02 mg/L and 0.11 mg/L ± 0.03 mg/L. The above indexes differed significantly between the two groups （P 〈 0.05 for all）. Serum APN levels showed a negative correlation with pre-pregnancy BMI, TG, HOMA-IR and FINS （r = -0.371, -0.459, -0.281, -0.321, P 〈 0.01 for all）. CONCLUSION： In GDM patients, APN and its receptors are closely related to insulin resistance, and clinical determination of APN may be helpful for the diagnosis and treatment of GDM.

关 键 词：脂联素 脂联素受体 妊娠期糖尿病 

分 类 号：R714.256[医药卫生—妇产科学]