泥浴疗法治疗膝骨关节炎疼痛的荟萃分析  

A meta-analysis of mud therapy on knee osteoarthritis pain

作　　者：邓桢翰[1] 杨拓[1] 李辉[1] 张屹[1] 李宇晟[1] 雷光华[1] 

机构地区：[1]中南大学湘雅医院骨科,湖南省长沙市410008

出　　处：《中国组织工程研究》2014年第15期2455-2460,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:泥浴疗法治疗膝骨关节炎一直受到研究者的重视,但其有效性在以往的各项研究中尚存在争议。目的:分析研究泥浴疗法治疗膝骨关节炎疼痛的有效性。方法:计算机检索Pubmed/Medline数据库以及手工检索相关文献的参考文献。所有检索截止至2013年3月9日。收集国内外公开发表的有关泥浴疗法治疗膝骨关节炎的随机对照试验和前瞻性对照试验。结果与结论:纳入Meta分析的研究共7个,累计研究对象410例。治疗组和对照组的目测类比疼痛评分(标准化标准差[SMD]-0.74)和WOMAC疼痛评分(标准化标准差[SMD]-0.30)组间差异有显著性意义。可见泥浴疗法可改善膝骨关节炎疼痛的症状。但此结论有待更多高质量的随机对照试验进一步证实。BACKGROUND：As a therapy means of osteoarthritis, mud therapy has attracted great attention from the researchers, but its effectiveness stil remains controversial in the previous studies. OBJECTIVE：To analyze the effectiveness of mud therapy for relieving knee osteoarthritis pain. METHODS：An online search through Pubmed/Medline database was performed, and the relevant literatures were manual y retrieved. The retrieval deadline was set on March 9, 2013. Randomized control ed trials and prospective control ed trials addressing mud therapy of knee osteoarthritis were col ected. RESULTS AND CONCLUSION：A total of seven studies of meta-analysis involving 410 cases were included. There was a significant difference between treatment group and control group in the visual analogue scale pain score （standardized mean difference：-0.74） and WOMAC pain score （standardized standard deviation：-0.30）. Mud therapy can attenuate knee osteoarthritis pain. But this conclusion needs to be confirmed by more high-quality randomized control ed trials.

关 键 词：组织构建 骨组织工程 疼痛 泥疗法 膝关节 骨关节炎 荟萃分析 

分 类 号：R318[医药卫生—生物医学工程]