同种异体骨移植后排斥反应的伤口处理：传统换药与负压封闭引流  

The treatment of wounds caused by rejection after allogeneic bone transplantation: traditional wound dressing and vacuum sealing drainage

作　　者：张弩[1] 张春[1] 刘世清[1] 

机构地区：[1]武汉大学人民医院骨三科,湖北省武汉市430060

出　　处：《中国组织工程研究》2014年第18期2933-2938,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:对于同种异体骨移植后排斥反应引起的伤口持续渗液,采用传统换药方式处理存在频繁换药、不能完全封闭伤口等问题。目的:对比传统换药与负压封闭引流处理同种异体骨移植后排斥反应引起伤口渗液的效果。方法:选择同种异体骨移植后发生排斥反应引起的伤口渗液患者45例,按患者意愿分为两组治疗,试验组27例,采用负压封闭引流技术治疗,对照组18例按传统换药处理。对比两组换药次数、创面愈合时间及伤口感染率。结果与结论:试验组平均换药次数为1.22次,伤口平均愈合时间为16.26 d,伤口感染率为4%;对照组平均换药次数为9.78次,伤口平均愈合时间为21.06 d,伤口感染率为28%。两组间换药次数、伤口愈合时间及伤口感染率比较差异有显著性意义(P<0.05)。提示采用负压封闭引流技术治疗同种异体骨移植后发生排斥反应引起的伤口渗液,可减少换药次数,缩短伤口愈合时间,降低感染发生率。BACKGROUND：In the treatment of wound sustained exudate caused by rejection after al ogeneic bone transplantation, traditional method of wound dressing not only needs frequent dressing changes, but also can not completely close the wound. OBJECTIVE：To compare the effect of traditional method and vacuum sealing drainage in the treatment of wound sustained exudate caused by rejection after al ograft bone transplantation. METHODS：A total of 45 patients who developed wound sustained exudates caused by rejection after al ogeneic bone transplantation, were randomly divided into test and control groups according to the wishes of patients. The test group included 27 patients who were treated with vacuum sealing drainage, and the control group included 18 patients who were treated with conventional dressing. Number of dressings, wound healing time and infection rates were detected and compared in the two groups. RESULTS AND CONCLUSION：In the test group the average number of dressings was 1.22, the wound average healing time were 16.26 days, infection rates were 4%. In the control group the average number of dressings was 9.78, the wound average healing time were 21.06 days, infection rates were 28%. There were significant differences in the wound healing time, the number of dressings and infection rates between the two groups （P〈0.05）. The vacuum sealing drainage can shorten wound healing time, reduce the number of dressings, and lower infection rates. Vacuum sealing drainage is an effective method for the treatment of wound sustained exudates caused by rejection after al ograft bone transplantation.

关 键 词：实验动物 组织构建 负压引流 骨移植 创面修复 伤口感染 

分 类 号：R318[医药卫生—生物医学工程]