生物材料修复半月板运动损伤:现实与未来  

Biomaterials for repair of sport-induced meniscal injuries: actuality and future

作　　者：王世哲[1] 

机构地区：[1]兰州商学院体育教学部,甘肃省兰州市730020

出　　处：《中国组织工程研究》2014年第16期2588-2593,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:生物材料的发展为膝关节半月板损伤提供了新的治疗方法,具有广阔的应用前景。目的:对生物材料修复运动性半月板损伤进行综述分析。方法:应用文献检索的方法获取生物材料修复运动性半月板损伤的相关研究文献,以"半月板;生物材料;修复"为检索词进行检索,选择研究内容与半月板损伤治疗及生物材料相关性较强的文献,排除重复分析,重点对7篇文献进行归纳分析。结果与结论:膝关节半月板周边区域有血运供应,具有一定的自我修复功能,无血运供应区域则无自我修复功能,出现损伤时选择生物替代材料进行植入修复治疗,根据来源分为天然生物支架材料和人工合成高分子生物支架材料,应用时根据生物材料与人体的相容性、弹力、韧性、强度等性能,选择合适的生物材料进行替代治疗。BACKGROUND：Biomaterials provide a new therapeutic approach to meniscal injuries, which has broad application prospects. OBJECTIVE：To review the effects of biomaterials in the meniscal repair after sports injury. METHODS：Literature search was performed to retrieve articles concerning biomaterials for repair of sport-induced meniscal injury. The keywords were “meniscus; biomaterials; repair” in Chinese. Repeated articles were excluded, and finaly seven articles were included in result analysis. RESULTS AND CONCLUSION： The surrounding areas of the meniscus with blood supply possess a certain self-healing capability, while those with no blood supply has no this self-healing capability. Therefore, biomaterial implantation is selected for these areas without blood supply. Biomaterial scaffolds are divided into natural biomaterial scaffolds and polymer biomaterial scaffolds. We should choose the appropriate scaffold in replacement therapy according to the compatibility, elasticity, toughness, and strength of biomaterials.

关 键 词：生物材料 软骨生物材料 修复 半月板 膝关节 透明质酸 胶原 聚羟基乙酸 聚乳酸 关节软骨 骨性关节炎 

分 类 号：R318[医药卫生—生物医学工程]