革兰阴性杆菌对碳青霉烯类抗生素耐药机制的研究进展  

Research progress of mechanisms of carbapenem resistance in Gram-negative bacillus

作　　者：曾章锐[1] 邵海枫[1] 

机构地区：[1]南京军区南京总医院解放军临床检验医学研究所,南京医学硕士研究生210002

出　　处：《医学研究生学报》2014年第5期536-541,共6页Journal of Medical Postgraduates

基　　金：全军医学科技"十二五"科研项目(CWS129811298)

摘　　要：对碳青霉烯类抗生素耐药的革兰阴性杆菌给人类健康造成严重的威胁,散发或地方性暴发的革兰阴性杆菌耐药菌不仅存在于医院感染,同时也存在于社区感染。获得性碳青霉烯酶、外膜蛋白的缺失或者减少以及外排泵主动排出药物是造成碳青霉烯类耐药的主要原因,文中对碳青霉烯类耐药机制的研究进展作一综述。The current worldwide emergence of resistance to the powerful antibiotic carbapenem in Gram-negative bacillus constitutes an important growing public health threat. Sporadic outbreaks or endemic situations with Gram-negative bacillus isolates not susceptible to carbapenems are now reported not only in hospital settings but also in the community. Acquired carbapenemases, the loss or reduce of outer membrane protein and overexpression of efflux pump are the most important determinants sustaining resistance to car- bapenems. This review summarizes the current knowledge on carbapenem resistance in Gram-negative bacillus.

关 键 词：革兰阴性杆菌 碳青霉烯酶 外膜蛋白 耐药机制 

分 类 号：R978.1[医药卫生—药品]