正常人血清Hepcidin水平及与铁代谢指标的相关性分析  

Correlation between serum hepcidin level and serum iron metabolism indexes in healthy adults

作　　者：李江 李向阳 

机构地区：[1]深圳市第六人民医院检验科,广东深圳518052

出　　处：《中华实用诊断与治疗杂志》2014年第6期578-580,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：深圳市科技计划项目(20113303)

摘　　要：目的分析正常人血清Hepcidin水平及与铁代谢指标的关系。方法测定24例正常人血清Hepcidin及血清铁、铁蛋白、转铁蛋白、总铁结合力、转铁蛋白饱和度、可溶性转铁蛋白受体1和血红蛋白水平,采用相关分析及多元线性逐步回归分析分析Hepcidin与各参数间的相关性。结果本组正常人血清Hepcidin水平18.6(16.0,25.1)μg/L,不同性别Hepcidin水平差异无统计学意义(P>0.05);Hepcidin水平与铁蛋白呈正相关(r=0.723,P=0.000),与转铁蛋白(r=-0.612,P=0.001)、总铁结合力(r=-0.646,P=0.001)、可溶性转铁蛋白受体1-铁蛋白指数(r=-0.566,P=0.004)呈负相关;多元线性逐步回归分析显示,转铁蛋白和血清铁浓度可作为Hepcidin的预测因子。结论健康成人Hepcidin水平与铁蛋白、转铁蛋白、总铁结合力等指标相关,转铁蛋白和血清铁浓度可作为Hepcidin水平的预测因子。Objective To investigate the serum level of hepcidin and its correlation with iron metabolism indexes in normal adults. Methods The serum levels of hepcidin and serum iron, ferritin, transferrin, total iron binding capacity, transferrin saturation, soluble transferrin receptor 1 and hemoglobin were determined in 24 normal adults, and correlation analysis and multivariate lineal regression method were adopted to study the correlation between hepcidin and relative iron metabolism indexes. Results The serum hepcidin level was 18. 6 （16. 0, 25. 1） μg/L, and there was no significant difference between genders （P 〉0.05）. Hepcidin level was positively correlated with ferritin （r=0. 723, P=0. 000） and negatively correlated with transferrin （r=- 0. 612, P= 0. 001）, total iron binding capacity （r=-0. 646, P= 0. 001 ） and soluble transferrin receptor 1-ferritin index （r=-0. 566, P = 0. 004）. Multivariable lineal regression method revealed that transferrin and serum iron were the predictors of serum hepcidin. Conclusions In healthy adults, serum hepcidin level is correlated with ferritin, transferrin and total iron binding capacity. Transferrin and serum iron can be used as predictors of hepcidin level.

关 键 词：HEPCIDIN 血清铁 铁蛋白 转铁蛋白 总铁结合力 转铁蛋白饱和度 可溶性转铁蛋白受体1 

分 类 号：R446.11[医药卫生—诊断学]