血必净注射液治疗AECOPD患者对血管内皮舒缩功能的影响  

Influence of Xuebijing injection on vasodilation and vasoconstriction function in the treatment of patients with AECOPD

作　　者：江庆[1,2,3] 吴升[1,2,3] 郝建[1,2,3] 李树雯[1,2,3] 钱钧[1,2,3] 

机构地区：[1]安徽医科大学解放军杭州临床学院 [2]南京军区杭州疗养院 [3]杭州128医院心肺康复中心,浙江杭州310007

出　　处：《临床肺科杂志》2014年第7期1169-1172,共4页Journal of Clinical Pulmonary Medicine

基　　金：南京军区重点课题基金(No 11Z037)

摘　　要：目的研究血必净注射液(XBJI)对AECOPD者血清ET-1、ADM含量及肺功能的影响。方法将63例AECOPD者随机分为常规治疗组设为A组30例和XBJI治疗组设为B组33例及选择健康体检老年人设为C组27例。A组常规治疗,B组常规治疗加用XBJI 60mg,静滴,2/d,疗程14天。测定治疗前后血清ET-1、ADM含量及FEV1%、FEV1/FVC的变化。正常对照组设为C组,不给药物治疗。结果 A、B两组治疗前血清ET-1、ADM含量明显高于C组,FEV1%、FEV1/FVC明显低于C组(均P<0.05);A、B两组治疗后血清ET-1、ADM含量及FEV1%、FEV1/FVC均明显改善(P<0.05),B组治疗后血清ET-1、ADM含量及FEV1%、FEV1/FVC改善程度比A组明显(P<0.05)。结论 XBJI可降低血清ET-1、ADM含量,对ET-1与ADM有调节平衡作用,改善AECOPD患者血管舒缩功能和肺功能,对治疗AECOPD有显著疗效。Objective To investigate the effect of Xuebijing （ XBJ） injection on ET-1, ADM content and pulmonary function in patients with AEOPD. Methods 63 patients with AECOPD were randomly divided into the routine therapy group as the group A （30 cases） and the XBJ therapy group as the group B （33 cases）. 27 healthy people were taken as the control group. The group B was injected with XBJ twice a day for 14 day on the basic of the routine therapy. The changes of serum ET-1, ADM content and FEV1%, FEV1/FVC were measured before and after the treatment. The group C wasn＇t given any drug treatment. Results Before the treatment, the levels of serum ET-1 and ADM were significantly higher in the group A and B than in the group C （P〈0. 05）, and the value of FEV1%and FEV1/FVC was obviously lower in the group A and B than in the group C （P〈0. 05）. After the treatment, the levels of serum ET-1, ADM, FEV1%, and FEV1/FVC were significantly better （P〈0. 05）, and the improvement of FEV1%, FEV1/FVC was more pronounced in the group B than in the group A （ P〈0. 05 ） . Conclusion XBJ in-jection has significant effect to improve patients′vasomotor function and pulmonary function in AECOPD patients by reducing inflammation and the content of serum ET-1 and ADM.

关 键 词：慢性阻塞性肺疾病 血必净注射液 内皮素 肾上腺髓质素 

分 类 号：R563.9[医药卫生—呼吸系统]