活力苏口服液联合米氮平对气血亏虚型抑郁症患者血清去甲肾上腺素及5-羟色胺的影响  

The effect of Huolisu oral liquid combined with mirtazapine tablets on the expression of NE,5-HT in the patients with depression

作　　者：付晓丽[1,2] 庞淑兰[1] 

机构地区：[1]河北联合大学公共卫生学院,唐山063009 [2]河北省保定市第一中心医院老年病二科,071000

出　　处：《国际中医中药杂志》2014年第6期528-531,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的：观察活力苏口服液联合米氮平片对气血亏虚型抑郁症患者血清去甲肾上腺素（NE）、5-羟色胺（5-HT）的影响。方法收集2012年11月至2013年5月河北省保定市第一中心医院老年病二科患者75例，按随机数字表法将患者随机分为治疗组43例和对照组32例。对照组口服米氮平片，治疗组在对照组治疗基础上加服活力苏口服液。两组患者分别于治疗前、治疗后4周、8周分别进行汉密尔顿抑郁量表（HAMD）评分，同时检测血清NE、5-HT表达水平。结果治疗前两组患者HAMD评分及血清NE、5-HT水平差异无统计学意义（t值分别为0.501、0.520、0.611，P＞0.05）。治疗后4周、8周HAMD评分较对照组降低（t值分别为1.829、2.263，P＜0.05），血清5-HT水平升高（t值分别为2.119、2.870， P＜0.05），NE水平升高（t值分别为2.264、2.705，P＜0.05）。结论活力苏口服液联合米氮平片可减低气血亏虚型抑郁症患者HAMD评分，升高血清NE、5-HT水平，改善患者抑郁状态。Objective To observe the effect of Huolisu oral liquid combined with mirtazapine tablets on the expressions of NE and 5-HT in the patients with depression,and explore the therapeutic efficiency. Methods 75 patients with depression were randomly divided into a study group with 43 cases,which were treated with Huolisu oral liquid and mirtazapine tablets and a control group with 32 cases,which were only treated with mirtazapine tablets The Hamilton depression scale（HAMD）score, serum NE,and 5-HT were detected in the patients before the treatment and 4 and 8 weeks after the treatment separately. Results Before treatment,there were no statistical significance in HAMD score,serum depression NE and 5-HT（t=0.501, 0.520, 0.611,P〉0.05）. After treated for 4 and 8 weeks, compare with the control group, HAMD score was decreased（t=1.829、2.263, P〈0.05）, serum 5-HT was increased（t=2.119, 2.870, P〈0.05）,and NE was increased in the study group（t=2.264, 2.705,P〈0.05）. Conclusion Huolisu oral liquid combined with mirtazapine tablets can significantly decrease HAMD score,and increase serum NE and 5-HT level. The treatment can improve the depression symptoms in the patients with depression obviously.

关 键 词：活力苏口服液 米氮平片 抑郁症 去甲肾上腺素 5-羟色胺 

分 类 号：R277.7[医药卫生—中医学]