铜促进的三氟甲基化反应研究进展  

Recent Advances in Copper-Promoted Trifluoromethylation Reactions

作　　者：王光祖[1] 赫侠平 戴建军[1] 许华建[1,2] 

机构地区：[1]合肥工业大学医学工程学院,合肥230009 [2]先进功能材料与器件安徽省重点实验室,合肥230009

出　　处：《有机化学》2014年第5期837-851,共15页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21272050;21072040)资助项目~~

摘　　要：药物分子中含有三氟甲基可以有效改善其亲脂性、可吸收性以及代谢稳定性.因此,在有机分子中引入三氟甲基引起了人们的广泛关注.近年来,过渡金属催化的三氟甲基化反应得到了快速发展.其中,铜作为一种廉价且活性较高的催化剂能够实现多种三氟甲基化反应.从发生三氟甲基化反应的底物出发,综述了近年来卤代烃、硼试剂、C—H化合物、胺类、羧酸类化合物等的三氟甲基化反应研究进展.Drug molecules that contain trifluoromethyl group can effectively improve their lipophilicity, absorbability and metabolic stability. Thus, considerable attention has been paid to the introduce of tfifluoromethyl group into organic molecules. Recently, transition metal-catalyzed trifluoromethylation has been well developed. The cheap and high activity copper catalyst has also been used to access a variety of trifluoromethylation reactions. In this review, we focus the conversion of a number of substrates including halogenated hydrocarbons, boron reagents, C-H compounds, amines and carboxylic acids into the corresponding trifluoromethyl-containing compounds.

关 键 词：铜催化 三氟甲基化 三氟甲基试剂 

分 类 号：O621.251[理学—有机化学]