叶酸肠溶缓释片制备工艺及体外释药机理的研究  

Studies on enteric-coated sustained-release tablets and release mechanism preparation of folic acid

作　　者：邓雪[1] 孙敬蒙 张炜煜[3] 

机构地区：[1]吉林市鹿王制药股份有限公司,吉林吉林132022 [2]长春中医药大学研究生学院,长春130117 [3]长春中医药大学药学院,长春130117

出　　处：《华中师范大学学报（自然科学版）》2014年第3期370-374,共5页Journal of Central China Normal University：Natural Sciences

基　　金：吉林省科技发展计划项目(20130206041SF)

摘　　要：以叶酸的累积释放率为考察指标,采用单因素试验法,考察羟丙基甲基纤维素(HPMC)不同规格及用量,乳糖、糊精、硬脂酸镁的用量对药物体外释放行为的影响,确定处方的影响因素及水平;采用L9(34)正交试验对处方进行优化,确定最佳制备工艺参数;采用拟合方程对叶酸肠溶缓释片的释药机理进行研究,判断缓释片的释药行为.The release of folic acid was used as indicators to evaluate and optimize the formulation.The effets of hydroxypropyl methyl cellulose（HPMC） type and amount,the lactose amount,dextrin amount and magnesium stearate amount on release behavior in vitro were observed in single-factor testing method,determine the influential factors of the prescription optimization and level.Then the formulation was optimized by L9 （34） orthogonal design test to determine the best preparation technological conditions.The release of folic acid and adhesion phenomenon of the sustained-release tablets was used as indicators to evaluate and optimize the formulation.Using the fitting equation the release mechanism of the sustained-release tablets was studied and the release behavior of sustained-release tablets was determined.

关 键 词：叶酸 肠溶缓释片 制备工艺 释药机理 

分 类 号：R944.4[医药卫生—药剂学]