感染性脑损伤中橙皮苷对小鼠自主活动的影响  

Effect of hesperidin on locomotor activity of mice with infective brain injury induced by LPS

作　　者：吴健[1] 刘红芝[1] 温相如[2] 付燕燕[1] 张磊[3] 孙颖[3] 张芳[1] 刘永民[2] 董红燕[1] 刘永海[3] 宋远见[1] 

机构地区：[1]徐州医学院基础学院神经生物学研究中心,江苏徐州221004 [2]徐州医学院公共教育学院化学教研室,江苏徐州221004 [3]徐州医学院附属医院神经内科,江苏徐州221004

出　　处：《重庆医学》2014年第16期2026-2027,2031,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(31100762;81371300);江苏省高校自然科学研究项目(11KJB310013;13KJB310021);徐州医学院院长基金资助项目(2012KJZ06)

摘　　要：目的探索橙皮苷对脂多糖(LPS)诱导的感染性脑损伤小鼠在暗场环境中自主活动的影响。方法将45只ICR小鼠平均分为3组,即生理盐水组(对照组)、LPS组、橙皮苷组,每组15只,以ZH-ZFT型自主活动视频分析系统考察各组小鼠活动路程和穿格次数的情况。结果相对于对照组,LPS组小鼠的活动路程缩短,穿格次数减少,组间比较差异有统计学意义(P<0.05);相对于LPS组,橙皮苷组小鼠的活动路程延长,穿格次数增加,组间比较差异有统计学意义(P<0.05)。结论橙皮苷可显著增强LPS诱导的感染性脑损伤小鼠在暗场环境中的自主活动能力。Objective To study the effect of hesperidin on the locomotor activity of mice with infective brain injury induced by li-popolysaccharide （LPS）in the dark field environment.Methods 45 ICR mice were randomly divided into 3 groups：Saline group, LPS group and LPS＋Hesperidin group,15 mice in each group.The moving distance and the number of crossing line in the dark field were recorded using the ZH-ZFT locomotor activity video analysis system.ResultsThe LPS group had significantly shorter moving distance as well as lower frequency of the number of crossing line than those of the Saline group（P〈0.05）;compared with the LPS group,the Hesp group moved longer and crossed line more frequently,the differences between the two groups had statisti-cal significance （P〈0.05）.Conclusion Hesperidin could significantly improve the capacity for action in the dark field of mice with infective brain inj ury induced by LPS.

关 键 词：脑损伤 橙皮苷 自主活动 

分 类 号：R651.15[医药卫生—外科学]