曾升平主任医师治疗类风湿关节炎60例临床观察  

Clinical Observation of 60 Rheumatoid Arthritis Patients Treated by Chief Physician Zeng Shengping

作　　者：温博[1] 唐平[2] 曾升平[3] 

机构地区：[1]成都中医药大学 [2]北京京煤集团总医院,北京102300 [3]成都中医药大学附属医院名医堂,四川成都610075

出　　处：《云南中医中药杂志》2014年第5期1-4,共4页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：国家重点基础研究发展计划"973"项目(NO:2009CB522803)

摘　　要：目的观察附子复方不同增量方式治疗类风湿关节炎的有效性,并探讨其可能的作用机理。方法将60例确诊为类风湿关节炎寒湿阻络证的受试患者,随机分为治疗组(30例)和对照组(30例)。两组均予附子复方汤剂口服,每次150ml,每日3次,按照附子不同增量方式给药。疗程均为8周,观察1个疗程。观察西医疗效指征和中医临床证候积分改善情况的比较,以及治疗组每次加量后实验室指标值降低值的比较。结果治疗组疾病疗效总进步率96.67%,证候疗效总有效率100%,对照组疾病疗效总进步率60%,证候疗效总有效率36.67%,两组总体疗效比较有显著差异,P<0.05,治疗组疗效优于对照组。治疗组中,白附片剂量每翻倍增量一次后实验室指标的降低值明显优于此次增量前的实验室指标降低值,具有统计学意义(P<0.05)。结论使用附子翻倍增量方式治疗类风关节炎存在量效依存性,有着特殊的优势和广阔的前景。Objective： To observe the effectiveness of aconite compound incremental method on the treatment of rheumatoid arthritis patients and to explore its feasible working mechanism. Methods ：60 patients with cold -dampness blocking collaterals were randomly divided into a treatment group and a control group ,30 per group. The two groups were treated orally with the aconite compound decoction,150ml,3 times a day,according to the aconite compound incremental method. 8 weeks was a course of treatment. The observation of the effect indication of western medicine was made and the comparison of the clinical symptom score improvement of TCM as well as the lab index reduced value after each in- cremental dose were compared. Results ：The total effective improvement rate of the treatment group was 96. 67% ,and its syndrome total effective rate wasl00% while that of the control group was 60%, and its syndrome total effective rate was 36. 67%. The comparison of the total effect of the two groups showed significant difference（P 〈0. 05）. The effectiveness of the treatment group was better than that of the control group. In the treatment group ,when the dose of sliced white aco- nite doubled each time ,the lab index reduced value was significantly better than it was before, having statistical signifi- cance（P 〈 0. 05 ）. Conclusion：In the compound prescription, with the increasing dose of aconite, the index related to rheumatoid arthritis obviously decreased and the clinical symptom obviously improves, which indicates the aconite com- pound prescription has a dose - effect dependency on the treatment of rheumatoid arthritis.

关 键 词：类风湿关节炎 附子复方 附子多糖 临床观察 曾升平 

分 类 号：R593.22[医药卫生—内科学]