海南地区成人血清25羟基-维生素D参考区间的初步调查  

Primary survey for the reference intervals of serum 25-hydroxy vitamin D from adults in Hainan area

作　　者：熊燏[1] 钱士匀[1] 熊小泉 崔开媚[1] 蔡群芳[1] 邬强[1] 

机构地区：[1]海南医学院热带医学与检验医学院,海南海口571101 [2]罗氏诊断(上海)有限公司武汉办事处,湖北武汉430022

出　　处：《检验医学》2014年第5期464-467,共4页Laboratory Medicine

摘　　要：目的：对海南地区健康成人25羟基-维生素D（25 OH-D）参考区间进行调查，为合理补充维生素D提供科学依据。方法选择海南地区生活背景相似、年龄不同的健康体检者1978名（男1008名、女970名），收集对象的基本资料，采用电化学发光法测定所有对象的血清25 OH-D水平。按性别和年龄分别分组进行统计分析。结果调查所用的25 OH-D检测系统准确度、精密度良好。血清25 OH-D水平呈非正态分布，采用百分位数（P2．5～P97．5）设立参考区间。男、女性间血清25OH-D水平差异有统计学意义（P＜0．01）；≤50岁及＞50岁男、女性之间血清25OH-D水平差异均有统计学意义（P均＜0．01）；男性≤50岁的参考区间为6．77～26．80 ng/mL，＞50岁的参考区间为4．51～19．73 ng/mL；女性≤50岁的参考区间为5．96～24．79 ng/mL，＞50岁的参考区间为3．71～16．34 ng/mL。结论针对海南地区人群的实际情况，建立了不同性别和年龄的25OH-D参考区间。Objective To survey the reference intervals of serum 25-hydroxy vitamin D（25OH-D）from adults in Hainan area,and provide scientific reference for reasonable supplement of vitamin D.Methods Basic data of 1 978 healthy subjects（1 008 males and 970 females）with similar livelihood background and different ages were collected, and the level of serum 25 OH-D was analyzed by electro-chemiluminescence.The subjects were classified according to sex and age,and the results were analyzed statistically.Results The accuracy and precision of the 25 OH-D detection system were good,and the levels of serum 25OH-D had non-Gaussian distribution.The reference intervals were established by percentile （P2.5-P97.5 ）.There were statistical significances of 25 OH-D between males and females （P50 years old among males and females（P50 years old was 4.51-19.73 ng/mL.The reference interval of females ≤50 years old was 5.96-24.79 ng/mL and that of females 〉50 years old was 3.71-16.34 ng/mL.Conclusions The reference interval for specific sex and age should be established for the population of Hainan area.

关 键 词：25羟基-维生素D 成人 参考区间 

分 类 号：R446.1[医药卫生—诊断学]