沙美特罗替卡松吸入对哮喘患者血清炎症介质水平的影响  

Influence of salmeterol fluticasone inhalation on serum inflammatory mediators of asthma patients

作　　者：张宇虹[1] 任疆[2] 

机构地区：[1]浙江省绍兴市人民医院干部病房,绍兴312000 [2]浙江省绍兴市人民医院急诊科,绍兴312000

出　　处：《实用药物与临床》2014年第5期551-553,共3页Practical Pharmacy and Clinical Remedies

基　　金：2012浙江省医药卫生科技项目(2012ZHB023)

摘　　要：目的探讨沙美特罗替卡松吸入对哮喘患者血清炎症介质水平的影响。方法选择80例哮喘急性发作期患者,随机分为观察组和对照组。两组患者均予以抗感染、止咳祛痰和解痉平喘等对症治疗。观察组加用沙美特罗替卡松吸入,1吸/次,2次/d;对照组予以口服茶碱缓释片,0.1 g/次,2次/d,两组均连用8周。观察两组患者治疗前和治疗后血清白细胞介素(IL)-4、8、9和10水平的变化,并进行疗效及安全性评价。结果治疗8周后,两组患者血清IL-4、8和9水平均明显下降,血清IL-10水平均明显上升(P<0.05或P<0.01),且观察组下降或上升值较对照组更明显(P<0.05);同时观察组的临床总有效率明显高于对照组(χ2=4.11,P<0.05);两组治疗期间不良反应较轻,无严重的药物不良反应。结论沙美特罗替卡松吸入治疗哮喘疗效肯定,安全性较好,作用与其能降低血清IL-4、8和9水平,提高血清IL-10水平,抑制气道炎症反应密切相关。Objective To discuss the influence of salmeterol fluticasone inhalation on serum inflammatory mediators of asthma patients. Methods 80 cases of asthma patients in acute stage of attack were randomly divided into observation group and control group. The patients in the two groups were given anti-infection,resolving phlegm and relieving cough,relieving spasmolysis and asthma,etc treatment. The patients in observation group were given salmeterol fluticasone inhalation one suction per time,two times daily for 8 weeks;while the patients in control group were given theophylline sustained release tablets 0. 1 g,one time,two times daily for 8 weeks. The changes of serum interleukin-4,8,9 and 10（ IL-4,8,9 and 10） levels were observed before and after medical treatment,and the effect and security were carried on as well. Results After 8 weeks’ medical treatment,the serum IL-4,8 and 9 levels of patients in the two groups declined obviously,while the serum IL-10 level rose obviously（P ＆lt; 0. 05 or P ＆lt; 0. 01）,and the declining or rising rate in observation group was much higher than that in control group（P ＆lt; 0. 05）. The total clinical efficiency in observation group was much higher than that in control group（χ2= 4. 11,P ＆lt; 0. 05）. During the medical treatment,there were no serious drug adverse reactions（ADR）. Conclusion The inhalation of salmeterol fluticasone has reliable effect on patients with asthma,its mechanism is related to lowering IL-4,8 and 9 levels,improving IL-10 level,and inhibiting the airway inflammation.

关 键 词：哮喘 沙美特罗替卡松 炎症介质 

分 类 号：R562.25[医药卫生—呼吸系统]